ArticleInternational journal of clinical and experimental pathology2019
Correlation between CK1α and β-catenin Ser45-phosphorylation in patients with esophageal squamous cell carcinoma.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors at 1 institution in 1 country.
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Abstract
Wnt/β-catenin signaling plays important role in development and tumorigenesis. The accumulation of β-catenin in cytoplasm/nucleus leads to many diseases including cancer. In the normal cells, β-catenin is phosphorylated by CKIα and GSK-3, then phosphorylated β-catenin is sequentially degraded. However, the exact role and correlation of CK1α and β-catenin Ser45-phosphorylation in esophageal squamous cell carcinoma (ESCC) remains little known. PURPOSE: The present study was aimed at exploring the role and the correlation between the expression of CK1α and β-catenin Ser45-phosphorylation in ESCC.
methodsThe expression of CK1α and β-catenin Ser45-phosphorylation were detected by immunohistochemical technique in 90 cases of ESCC and their corresponding adjacent nonneoplastic esophageal tissues (n=90), and evaluated the correlation between the expression of CK1α, phosphorylation at Ser45 of β-catenin and clinicopathological parameters of ESCC patients.
resultsThe lever of the expression of CK1α in ESCC was 63.3% (57/90), significantly lower than that in nonneoplastic esophageal tissues was 84.4% (76/90), (X
conclusionCK1α and β-catenin Ser45-phosphorylation may play an important role in the pathogenesis and development of ESCC, and provide clinically useful information.
Indexed as
Identifiers
31933784PMC6949772W3006498499What OpenQuestion holds
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