ArticleInternational journal of clinical and experimental pathology2019
Fascin expression in urinary bladder urothelial carcinoma correlates with unfavourable prognosis.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- FSCN1 acts as a promising therapeutic target in the blockade of tumor cell motility: a review of its function, mechanism, and clinical significance.Journal of Cancer · 2022Review
- Fascin actin-bundling protein 1 in human cancer: promising biomarker or therapeutic target?Molecular therapy oncolytics · 2021Review
- Prognostic significance ofJournal of Cancer · 2021Article
- Cytoskeletal Remodeling in Cancer.Biology · 2020Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUrinary bladder crothelial carcinoma (UCB) is the most common urinary bladder neoplasm. The present study aims at investigating immunostaining of fascin in UCB in relation to clinicopathologiccriteria in Saudi Arabia.
methodsThis study utilised 122 UCB and 25 apparently normal urothelium archival pathologic samples prior to local or systemic therapy. Tissue microarrays were constructed and the generated TMA blocks were used for Immunohistochemical staining. The mouse anti-fascin monoclonal antibody was used. A 25% was used to specify low and high fascin immunostaining.
resultsFascin immunostaining was detected in UCB and apparently normal urothelium. High immunostaining was statistically less frequent than low fascin immunostaining (
conclusionHigh fascin immunostaining in UCB was associated with adverse prognostic factors and may be used as an independent prognostic marker. Fascin was detected in apparently normal urothelium and may contribute to UCB carcinogenesis. Further investigations (molecular and clinical) are required to understand the molecular interaction of fascin with UCB and its possible therapeutic applications.
Indexed as
Identifiers
31933780PMC6949743W3026692180What OpenQuestion holds
Registered trials
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