ArticleInternational journal of clinical and experimental pathology2019
NDRG3 protein expression is associated with aggressive biologic phenotype and unfavorable outcome in patients with invasive breast cancer.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The trial behind it
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Regulatory Potential of piRNAs TargetingGenes · 2026Article
- Anti-proteolytic regulation of KRAS by USP9X/NDRG3 in KRAS-driven cancer development.Nature communications · 2025Article
- Unraveling the protein kinase C/NDRG1 signaling network in breast cancer.Cell & bioscience · 2024Article
- NDRGs in Breast Cancer: A Review and In Silico Analysis.Cancers · 2024Review
- NDRG1 acts as an oncogene in triple-negative breast cancer and its loss sensitizes cells to mitochondrial iron chelation.Frontiers in pharmacology · 2024Article
- Article
- Cancer Angiogenesis and Opportunity of Influence on Tumor by Changing Vascularization.Journal of personalized medicine · 2022Review
- Relationship between serum NDRG3 and papillary thyroid carcinoma.Frontiers in endocrinology · 2022Article
- Immunohistochemical Expressions of Senescence-Associated Secretory Phenotype and Its Association With Immune Microenvironments and Clinicopathological Factors in Invasive Breast Cancer.Pathology oncology research : POR · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The N-myc downstream regulated gene (NDRG) protein family consists of 4 members (NDRG1, NDRG2, NDRG3, and NDRG4), that have been reported to be aberrantly expressed in human cancers. Furthermore, NDRG3 protein expression is known to promote tumor angiogenesis and cell growth. The aim of this study was to investigate the clinical significance of NDRG3 expression in invasive breast cancer (IBC). NDRG3 expression was evaluated immunohistochemically in tissue microarrays of 1339 IBC samples, and associations between NDRG3 expression and clinicopathologic parameters, including prognosis, were examined. NDRG3 protein expression was observed in 194 (14.5%) cases, and found to be associated with an age of ≥ 50 yrs (
Indexed as
Identifiers
31933778PMC6949768W3007494343What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.