ArticleInternational journal of clinical and experimental pathology2019
Variant sublineages of human papillomavirus type 16 predispose women to persistent infection characterized by a sequence analysis of the E6, L1, and LCR regions.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 6 citations in OpenAlex.
- Article
- Article
- Prevalence and distribution of human papillomavirus (HPV) in Luoyang city of Henan province during 2015-2021 and the genetic variability of HPV16 and 52.Virology journal · 2022Article
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9 authors at 2 institutions in 2 countries.
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Abstract
backgroundOne of the precursors of cervical cancer is persistent infection with human papillomavirus (HPV), especially high-risk HPV. The aim of this study was to verify the relationship between HPV16 variants and persistent viral infection.
methodsThree-hundred and eighty-six Chinese women who had a low-grade squamous intraepithelial lesion (LSIL) or a lesion below LSIL with normal cellular morphology were selected and enrolled in this study. Flow-through hybridization and gene chip technology were applied to identify the HPV type, and a PCR-sequencing assay was performed to detect HPV16
resultsIn this population, 74.09% of HPV16 isolates belonged to the A4 sublineage, 24.87% to the A1/A2 sublineages, and 3.13% to B1/B2 sublineages. In addition, the A4 sublineage T178G (P<0.001) and the A1/A2 sublineages T350G and A442C (P<0.001) were associated with persistent HPV16 infection.
conclusionHPV16 E6 variants in the Shanghai Pudong District mainly belong to the A4 sublineage, and detection of the specific HPV
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31933750PMC6943999W3005592447What OpenQuestion holds
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