ArticleInternational journal of clinical and experimental pathology2019
Long non-coding RNA H19 promotes tumorigenesis of ovarian cancer by sponging miR-675.
Article in International journal of clinical and experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- An updated review of the H19 lncRNA in human cancer: molecular mechanism and diagnostic and therapeutic importance.Molecular biology reports · 2020Review
- The Good, the Bad, the Question-Cancers · 2020Review
- Review
Corrections and comments
- Retraction · 2019-02-01Falsification/Fabrication of Data · Investigation by Journal/Publisher · · Fei Ji, Bing Chen, Rong Du, Meng Zhang, Yanjia Liu, Yan Ding: Long non-coding RNA H19 promotes tumorigenesisof ovarian cancer by sponging miR-675. Int J Clin Exp Pathol 2019;12(1):113-122. (Retracted, Full text PDF).
- Retracted
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOvarian cancer is one of the six most common women's cancers in the world, and is found among the top three female genital tumors, which is lower than the rate of endometrial cancer and cervical cancer.
methodsThis study utilized miR-675 mimics and siRNA transfection to construct miR-675 overexpression and lower-expression model to investigate the effect of miR-675 on the regulation of ovarian cancer. Western blotting and RT-qPCR were applied for the quantitative testing of mRNA and protein expression. Apoptosis of podocytes was detected by TUNEL staining.
resultsH19 expression was also up-regulated. In vitro, H19 silencing after transfection with si-H19 could suppress proliferation and invasion. Luciferase reporter assay revealed a close link between miR-675 and H19 3'-UTR. Furthermore, combining experiments of miR-675 and H19 indicated that miR-675 could reverse the function of H19 on ovarian cancer.
conclusionOur study reveals the overexpression of H19 in ovarian cancer tissue and cells, and discovers an oncogenic role in ovarian cancer via sponging miR-675, providing a potential biomarker for early detection and prognosis of ovarian cancer.
Indexed as
Identifiers
31933725PMC6944020W3005647652What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.