ArticleNeural plasticity2019
Altered Brain Structure and Functional Connectivity Associated with Pubertal Hormones in Girls with Precocious Puberty.
Article in Neural plasticity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Characteristics of Executive Function in School-Aged Girls With Idiopathic Central Precocious Puberty.Brain and behavior · 2026Article
- Hypothalamic-superior frontal gyrus functional connectivity alterations and luteinizing hormone correlations in girls with central precocious puberty.Annals of pediatric endocrinology & metabolism · 2026Article
- Structural MRI assessment of hypothalamic alterations and cognitive implications in adolescents with rapid pubertal progression.BMC medical imaging · 2026Article
- Gonadotropins Across the Lifespan: Their role in the Neurodevelopment-Neurodegeneration Continuum.The Yale journal of biology and medicine · 2026Review
- Machine Learning-Powered fNIRS Detection of Idiopathic Central Precocious Puberty via Prefrontal Cortex Activation.BME frontiers · 2026Article
- Altered Brain Functional Connectivity and Topological Structural in Girls with Idiopathic Central Precocious Puberty: A Graph Theory Analysis Based on Resting-State fMRI.Children (Basel, Switzerland) · 2025Article
- Brain structural changes in girls with idiopathic central precocious puberty: a voxel-based morphometry and surface-based morphometry analysis.Frontiers in endocrinology · 2025Article
- Aberrant brain functional hubs and causal effective connectivity in menstrually-related and non-menstrually-related migraine without aura.Quantitative imaging in medicine and surgery · 2024Article
- Brain-derived neurotrophic factor, sex hormones and cognitive decline in male patients with schizophrenia receiving continuous antipsychotic therapy.World journal of psychiatry · 2023Article
- The Assessment of Brain Volume Differences in Idiopathic Central Precocious Puberty Girls; Comparison of Age-Matched Girls and Normal Puberty Girls.Children (Basel, Switzerland) · 2021Article
- Spectral dynamic causal modelling in healthy women reveals brain connectivity changes along the menstrual cycle.Communications biology · 2021Article
- Higher Executive Control Network Coherence Buffers Against Puberty-Related Increases in Internalizing Symptoms During the COVID-19 Pandemic.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- Evidence Limitations in Determining Sexually Dimorphic Outcomes in Pediatric Post-Traumatic Hypopituitarism and the Path Forward.Frontiers in neurology · 2020Review
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pubertal hormones play an important role in brain and psychosocial development. However, the role of abnormal HPG axis states in altering brain function and structure remains unclear. The present study is aimed at determining whether there were significant differences in gray matter volume (GMV) and resting state (RS) functional connectivity (FC) patterns in girls with idiopathic central precocious puberty (CPP) and peripheral precocious puberty (PPP). We further explored the correlation between these differences and serum pubertal hormone levels. To assess this, we recruited 29 idiopathic CPP girls and 38 age-matched PPP girls. A gonadotropin-releasing hormone (GnRH) stimulation test was performed, and pubertal hormone levels (including luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), prolactin, and cortisol) were assessed. All subjects underwent multimodal magnetic resonance imaging of brain structure and function. Voxel-based morphometry (VBM) analysis was paired with seed-to-voxel whole-brain RS-FC analysis to calculate the GMV and RS-FC in idiopathic CPP and PPP girls. Correlation analyses were used to assess the effects of pubertal hormones on brain regions with structural and functional differences between the groups. We found that girls with CPP exhibited decreased GMV in the left insula and left fusiform gyrus, while connectivity between the left and right insula and the right middle frontal gyrus (MFG), as well as the left fusiform gyrus and right amygdala, was reduced in girls with CPP. Furthermore, the GMV of the left insula and peak FSH levels were negatively correlated while higher basal and peak E2 levels were associated with increased bilateral insula RS-FC. These findings suggest that premature activation of the HPG axis and pubertal hormone fluctuations alter brain structure and function involved in the cognitive and emotional process in early childhood. These findings provide vital insights into the early pathophysiology of idiopathic CPP.
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