Evidence map›Paper›PMID 31933573›Full record

ArticleTransfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie2019

Risk Factors for Transfusion after Orthotopic Liver Transplantation.

Ana Paula Hitomi Yokoyama, José Mauro Kutner, Araci Massami Sakashita, Cristiane Yoshie Nakazawa, Tatiana Almeida Omura de Paula, Raffael Perreira Cezar Zamper, Pamella Tung Pedroso, Marcio Dias de Almeida, Sergio Paiva Meira Filho, Fernanda Andrade Orsi

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Article in Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ana Paula Hitomi YokoyamaHemotherapy and Cell Therapy Department, Hospital Israelita Albert Einstein, São Paulo, Brazil.
José Mauro KutnerHemotherapy and Cell Therapy Department, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Araci Massami SakashitaHemotherapy and Cell Therapy Department, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Cristiane Yoshie NakazawaHemotherapy Department, Hospital Municipal Vila Santa Catarina, São Paulo, Brazil.
Tatiana Almeida Omura de PaulaHemotherapy Department, Hospital Municipal Vila Santa Catarina, São Paulo, Brazil.
Raffael Perreira Cezar ZamperAnesthesiology Department, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Pamella Tung PedrosoLiver Transplantation Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Marcio Dias de AlmeidaLiver Transplantation Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Sergio Paiva Meira FilhoLiver Transplantation Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Fernanda Andrade OrsiDepartment of Clinical Pathology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTransfusion of blood products during orthotopic liver transplantation (OLT) is associated with increased morbidity and mortality. Although risk factors associated with intraoperative transfusion requirements have been widely assessed, published data on the prediction of postoperative transfusion requirements are sparse.

objectivesThe aim of this study was to evaluate risk factors for postoperative allogeneic transfusion requirements in OLT.

methodsClinical characteristics and intraoperative parameters of 645 consecutive adult patients undergoing OLT were retrospectively reviewed. Multivariate logistic regression was used to determine the main determinants for postoperative transfusion requirements.

resultsDeterminants of postoperative transfusion requirements of any blood product in the postoperative period were the number of blood products transfused in the intraoperative period (OR 1.17, 95% CI 1.08-1.28), warm ischemia time (OR 1.05, 95% CI 1.02-1.08), MELD score (OR 1.05, 95% CI 1.01-1.08) and hepatocellular carcinoma (OR 0.45, 95% CI 0.28-0.72). A dose-dependent effect between the number of units transfused in the intraoperative period and transfusion requirements in the postoperative period was also observed. The relative risk of postoperative allogeneic transfusion of any blood component was 5.9 (95% CI 3.4-10.4) for patients who received 1-2 units in the intraoperative period, 7.3 (95% CI 3.6-14.7) for those who received 3-5 units in the intraoperative period, and 11.1 (95% CI 4.7-26.4) for those who received 6 or more units, when compared to no intraoperative blood transfusion.

conclusionOur study demonstrated an association between intraoperative transfusion and warm ischemia time with postoperative transfusion requirements. The identification of risk factors for transfusion in the postoperative period may improve management of these patients by increasing awareness to bleeding complications in this high-risk population and by expanding hemostasis monitoring to the postoperative period.

Indexed as

MELD scoreOrthotopic liver transplantationRisk factorsTransfusion

Identifiers

PMID31933573
PMCPMC6944942

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.