ArticleNeuropsychiatric disease and treatment2019
Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders.
Article in Neuropsychiatric disease and treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The correlation between prenatal maternal active smoking and neurodevelopmental disorders in children: a systematic review and meta-analysis.BMC public health · 2023Pooled it
- Efficacy of high-dose vs. low-dose vitamin D₃ supplementation in children with chronic tic disorders: a randomized controlled trial.Nutrition journal · 2025Trial
- Emerging Therapeutic Approaches for Tic Alleviation in Tourette Syndrome: The Role of Micronutrients.Neurology international · 2025Review
- Prolonged screen time is associated with increased severity of tic symptoms in children with tic disorders.Italian journal of pediatrics · 2025Article
- Effects and mechanisms of vitamins A and D on behavior associated with Tourette syndrome in rats.Frontiers in nutrition · 2025Article
- The intricate interplay between dietary habits and cognitive function: insights from the gut-brain axis.Frontiers in nutrition · 2025Review
- Clinical characteristics and serum 25-hydroxyvitamin D levels in children with febrile seizures in China.Scientific reports · 2024Article
- Vitamin D3 improves iminodipropionitrile-induced tic-like behavior in rats through regulation of GDNF/c-Ret signaling activity.European child & adolescent psychiatry · 2024Article
- Circulating retinol and 25(OH)D contents and their association with symptoms in children with chronic tic disorders.European child & adolescent psychiatry · 2024Article
- Vitamin D levels in children and adolescents with chronic tic disorders: a multicentre study.European child & adolescent psychiatry · 2022Article
- Tourette Syndrome Treatment Updates: a Review and Discussion of the Current and Upcoming Literature.Current neurology and neuroscience reports · 2022Review
- Correlation between Serum Levels of Vitamin A and Vitamin D with Disease Severity in Tic Disorder Children.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Correlation Between Tic Disorders and Serum 25-Hydroxyvitamin D Levels in Chinese Children.Frontiers in pediatrics · 2022Article
- Association of Prenatal Maternal Anemia with Tics and Tourette's Syndrome in Offspring.Journal of personalized medicine · 2021Article
- The 5 Pillars in Tourette Syndrome Deep Brain Stimulation Patient Selection: Present and Future.Neurology · 2021Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeVitamin D deficiency has been found in children with chronic tic disorders (CTDs). Our previous data showed that serum 25-hydroxyvitamin D [25(OH)D] level in children with CTDs was lower than that of the healthy controls and lower serum 25(OH)D level was associated with increased severity of the tic disorder. Thus, we intend to further verify this phenomenon and examine the effect of vitamin D3 on CTDs. PATIENTS AND
methodsIn total, 120 children with CTDs and 140 normal controls were enrolled in this study, with 36/120 of those in the CTD group receiving vitamin D3 treatment for 3 months. The Yale Global Tic Severity Scale (YGTSS) and Clinical Global Impression of Severity of Illness (CGI-SI) were, respectively, used to evaluate the tic severity. High-performance liquid chromatography and tandem mass spectrometry were used to measure serum 25(OH)D level.
resultsThose children with CTDs exhibited significantly lower 25(OH)D levels than did healthy controls, and these reduced 25(OH)D levels were linked to increasing severity of tic symptoms. After treatment with supplemental vitamin D3, serum 25(OH)D level and scores of YGTSS total, motor tics, phonic tics, total tic, impairment, and CGI-SI improved significantly in children with CTDs without any adverse reactions.
conclusionSupplementation vitamin D3, given its low cost and excellent safety, may be an effective means of improving symptoms in certain children with CTDs.
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