Evidence map›Paper›PMID 31933261›Full record

ReviewMolecular biology reports2020

D-ribose and pathogenesis of Alzheimer's disease.

Mehjbeen Javed, Md Irshad Ahmad, Hina Javed, Sufia Naseem

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mehjbeen JavedAquatic Toxicology Research Laboratory, Department of Zoology, Aligarh Muslim University, Aligarh, U.P., India.
Md Irshad AhmadDepartment of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, U.P., India.
Hina JavedDepartment of Chemistry, Aligarh Muslim University, Aligarh, U.P., India.
Sufia NaseemDepartment of Biochemistry, Faculty of Medicine, Aligarh Muslim University, Aligarh, U.P., India. sufianaseem@gmail.com.
Aligarh Muslim University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is estimated that the global prevalence of dementia will rise as high as 24 million and predicted to be double in every 20 years which is attributed to the fact that the ageing population is increasing and so more individuals are at risk of developing neurodegenerative diseases like Alzheimer's. Many scientists favored glycation of proteins such as tau, amyloid beta (Aβ) etc. as one of the important risk factor in Alzheimer's disease (AD). Since, D-ribose shows highest glycation ability among other sugars hence, produces advanced glycation end products (AGEs) rapidly. However, there are several other mechanisms suggested by researchers through which D-ribose may cause cognitive impairments. There is a concern related to diabetic patients since they also suffer from D-ribose metabolism, may be more prone to AD risk. Thus, it is imperative that the pathogenesis and the pathways involved in AD progression are explored in the light of ribosylation and AGEs formation for identifying suitable diagnostics marker for early diagnosis or finding promising therapeutic outcomes.

Indexed as

Disease SusceptibilityAlzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsDisease ManagementGlycation End Products, AdvancedGlycosylationHumansNeurodegenerative DiseasesNeuronsProtein Processing, Post-TranslationalProteolysisReceptor for Advanced Glycation End ProductsRiboseSignal TransductionAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAPP protein, humanGlycation End Products, AdvancedReceptor for Advanced Glycation End ProductsRiboseAGEAlzheimer’sAmyloid βD-riboseGlycationRAGETau

Identifiers

PMID31933261
OpenAlexW2999826415

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.