Evidence map›Paper›PMID 31933212›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2020

An Integrated Strategy for Identifying Targets of Ubiquitin-Mediated Degradation in CD4+ T Cells.

Natania S Field, Claire E O'Leary, Joseph M Dybas, Hua Ding, Paula M Oliver

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Natania S FieldThe University of Pennsylvania, Philadelphia, PA, USA.
Claire E O'LearyDepartment of Medicine, University of California-San Francisco, San Francisco, CA, USA.
Joseph M DybasThe University of Pennsylvania, Philadelphia, PA, USA.
Hua DingCell Pathology Division, Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Paula M OliverThe University of Pennsylvania, Philadelphia, PA, USA. paulao@pennmedicine.upenn.edu.

Funding

Nedd4-family adaptors and their regulation of T cell function.R01AI093566 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI OLIVER, PAULA MARIA · 2011 to 2020
$4.2M
Mechanisms of ubiquitin pathway activation and functionR01AI114515 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI OLIVER, PAULA MARIA · 2015 to 2019
$2.1M
Nedd4-family ubiquitination networks that regulate T cell functionR01AI080765 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI OLIVER, PAULA MARIA · 2009 to 2012
$1.6M
NIAID NIH HHS R01 AI080765NIAID NIH HHS R01 AI093566NIAID NIH HHS R01 AI114515
6 · The paper itself

Abstract

Ubiquitination is a crucial component of many immune processes. While ubiquitin-mediated degradation is essential to T cell activation via T cell receptor signaling, the specific E3 ligases and substrates involved are not well-understood. Here, we describe a strategy integrating RNA, protein, and posttranslational modification datasets to identify targets of ubiquitin-mediated degradation. When integrated, these assays can provide broad insight into how this posttranslational modification regulates protein function and influences T cell biology.

Indexed as

CD4-Positive T-LymphocytesLymphocyte ActivationProteolysisReceptors, Antigen, T-CellSignal TransductionUbiquitinUbiquitin-Protein LigasesReceptors, Antigen, T-CellUbiquitinUbiquitin-Protein LigasesDiglycine remnant profilingLymphocyteSignalingT cellUbiquitin

Identifiers

PMID31933212
PMCPMC7549384

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.