ArticleJournal of cardiovascular translational research2020
A Novel In-hospital Congestion Score to Risk Stratify Patients Admitted for Worsening Heart Failure (from ASCEND-HF).
Article in Journal of cardiovascular translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Assessing congestion in heart failure: tools are already available, but integration is key.Heart failure reviews · 2026Review
- Pro-adrenomedullin associates with congestion in acute heart failure patients.ESC heart failure · 2024Article
- Developing Clinical Risk Prediction Models for Worsening Heart Failure Events and Death by Left Ventricular Ejection Fraction.Journal of the American Heart Association · 2023Article
- Congestion in heart failure: a contemporary look at physiology, diagnosis and treatment.Nature reviews. Cardiology · 2020Review
- A Contemporary Picture of Congestion in Heart Failure: from Dropsy Impression to Multifaceted Reality.Journal of cardiovascular translational research · 2020Article
Corrections and comments
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Authors and funding
11 authors.
Funding
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Abstract
Patients hospitalized for heart failure (HF) remain at high risk for early readmission. A post hoc analysis was performed of the biomarker substudy of the ASCEND-HF trial. An in-hospital congestion score was derived using orthopnea, pedal edema, and NT-proBNP levels. Its added prognostic value beyond traditional risk factors was assessed by determining the net reclassification index (NRI). Study participants (n = 884) had a median age (years) of 67 (55-77), 68% were male, and the median (25th-75th) ejection fraction (%) was 26 (20-40). After adjustment, increasing congestion score was associated with 30-day all-cause mortality or HF hospitalization (odds ratio = 1.51, 95% confidence interval [CI] 1.28-1.77, p < 0.001) and 180-day all-cause mortality (hazard ratio = 1.48, 95% CI 1.28-1.72, p < 0.001). However, adding the congestion score to the multivariable model did not significantly impact the NRI. A higher in-hospital congestion score portended a poor short-term prognosis but did not significantly reclassify risk.
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