Evidence map›Paper›PMID 31933054›Full record

ArticleAnnals of intensive care2020

Surfactant protein D (SP-D) gene polymorphism rs721917 is an independent predictor of acute kidney injury development in sepsis patients: a prospective cohort study.

Jiao Liu, Jianying Yao, Lidi Zhang, Yizhu Chen, Hangxiang Du, Zhenliang Wen, Dechang Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
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Article in Annals of intensive care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jiao LiuDepartment of Critical Care Medicine, Shanghai Jiaotong University, School of Medicine, Ruijin Hospital North, Shanghai, 201801, China.
Jianying YaoIntensive Care Unit, The First People's Hospital of Kunshan, Kunshan, 215300, China.
Lidi ZhangDepartment of Critical Care Medicine, Shanghai Jiaotong University, School of Medicine, Ruijin Hospital North, Shanghai, 201801, China.
Yizhu ChenDepartment of Critical Care Medicine, Shanghai Jiaotong University, School of Medicine, Ruijin Hospital North, Shanghai, 201801, China.
Hangxiang DuDepartment of Critical Care Medicine, Shanghai Jiaotong University, School of Medicine, Ruijin Hospital North, Shanghai, 201801, China.
Zhenliang WenDepartment of Critical Care Medicine, Shanghai Jiaotong University, School of Medicine, Ruijin Hospital North, Shanghai, 201801, China.
Dechang ChenDepartment of Critical Care Medicine, Shanghai Jiaotong University, School of Medicine, Ruijin Hospital North, Shanghai, 201801, China. 742717045@qq.com.
Ruijin Hospital · CNJiangsu University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurrently, there are no reliable predictors of risk of development and severity of acute kidney injury (AKI) in septic patients. The surfactant protein D (SP-D) polymorphism rs721917C/T is associated with a greater susceptibility to AKI in the Chinese population. Our aim was to evaluate the value of SP-D polymorphisms rs721917C/T and of plasma SP-D levels to predict the risk of development of AKI (defined with KDIGO criterion) in septic patients.

methodsThe study enrolled septic patients admitted to the Critical Care Department of two tertiary care hospitals. SP-D rs721917C/T polymorphisms were determined using the PCR-SSP method. Plasma SP-D and urine NGAL contents were measured using commercially available ELISA kits.

results330 septic patients were included. Their SOFA scores were 12 ± 3. Patients with AKI (n = 156) had higher plasma SP-D levels (median: 153 ng/mL, range 111-198 ng/mL) and urinary NGAL levels (median: 575 ng/mL, range 423-727 ng/mL) than those without AKI (SP-D median: 124 ng/mL, range 81-159 ng/mL, P = 0.001; NGAL median: 484 ng/mL, range 429-573 ng/mL). Plasma SP-D levels of AKI patients were correlated with urinary NGAL contents (r = 0.853). In 32 patients receiving continuous renal replacement therapy (CRRT), plasma SP-D levels correlated with duration of CRRT (r = 0.448). The area under the receiver operating characteristic curve for plasma SP-D levels to predict AKI was 0.84. Patients with AKI had a higher rate of rs721917 CC genotype (AKI: 35% vs. non-AKI: 20%; P = 0.012), but a significantly lower rate of TT genotype (AKI: 19% vs. non-AKI: 26%; P = 0.005). SP-D rs721917 CC genotype was an independent predictor of AKI (P = 0.044) and mortality (P = 0.014).

conclusionOur study showed that increased plasma SP-D level is associated with a higher risk of AKI in patients with sepsis. The SP-D rs721917CC genotype is an independent and significant predictor of AKI development and mortality of septic patients. The SP-D rs721917C/T polymorphisms should be further studied as diagnostic and prognostic biomarkers to facilitate early recognition of AKI.

Identifiers

PMID31933054
PMCPMC6957590
OpenAlexW3005071653

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.