Evidence map›Paper›PMID 31933020›Full record

ArticleAIDS and behavior2020

A Behavioral Adherence Intervention Improves Rates of Viral Suppression Among Adherence-Challenged People Living with HIV in South India.

Maria L Ekstrand, Elsa Heylen, Matilda Pereira, Jacob D'Souza, Shoba Nair, Amanda Mazur, Ranjani Shamsundar, B N Ravi Kumar, Sara Chandy

Abstract read
In one paragraph

Article in AIDS and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maria L EkstrandDepartment of Medicine, Center for AIDS Prevention Studies, University of California, 550 16th Street, 3rd Floor, Box 0886, San Francisco, CA, 94143, USA. Maria.Ekstrand@ucsf.edu.ORCID http://orcid.org/0000-0001-7587-2899
Elsa HeylenDepartment of Medicine, Center for AIDS Prevention Studies, University of California, 550 16th Street, 3rd Floor, Box 0886, San Francisco, CA, 94143, USA.
Matilda PereiraSt John's Research Institute, St John's National Academy of Health Sciences, Bangalore, India.
Jacob D'SouzaSt John's Research Institute, St John's National Academy of Health Sciences, Bangalore, India.
Shoba NairSt John's Medical College and Hospital, St John's National Academy of Health Sciences, Bangalore, India.
Amanda MazurDepartment of Medicine, Center for AIDS Prevention Studies, University of California, 550 16th Street, 3rd Floor, Box 0886, San Francisco, CA, 94143, USA.
Ranjani ShamsundarSt John's Medical College and Hospital, St John's National Academy of Health Sciences, Bangalore, India.
B N Ravi KumarKarnataka State AIDS Prevention Society, Bangalore, India.
Sara ChandySt John's Medical College and Hospital, St John's National Academy of Health Sciences, Bangalore, India.

Funding

Ujima Mentoring ProgramP30MH062246 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Sheri Ann Lippman · 2001 to 2026
$57.4M
Tel-Me-Box: Validating and testing a novel, low-cost, real-time monitoring device with hair level analysis among adherence-challenged patientsR01MH109310 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EKSTRAND, MARIA L., GANDHI, MONICA · 2016 to 2020
$3.1M
Enhancing HIV treatment adherence in Bangalore: The Chetana studyR01MH095659 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EKSTRAND, MARIA L. · 2011 to 2016
$2.4M
NIMH NIH HHS P30 MH062246NIMH NIH HHS R01 MH095659NIMH NIH HHS R01MH095659NIMH NIH HHS R01 MH109310
6 · The paper itself

Abstract

The success of antiretroviral therapy (ART) has led to both extended life expectancy and improved quality of life among people living with HIV (PLWH). To maximize the efficacy of first line ART regimens in low- and middle-income countries (LMIC), we need culturally-relevant interventions that empower participants to reduce barriers to long-term uninterrupted adherence. The Chetana adherence intervention trial was designed in collaboration with local community groups as a comprehensive wellness program for adherence-challenged PLWH and included peer-led adherence support, yoga, nutrition, information about local resources, and individual counseling using motivational interviewing techniques. Intervention arm participants were almost twice as likely to be virally suppressed at their 12-month follow-up visit (AOR = 1.98; 95% CI [1.2, 3.23]) as were participants in the active control arm. They were also about twice as likely as control arm participants to self-report ≥ 95% adherence (AOR = 1.86, 95% CI [1.09, 3.15]), and as having eliminated individual adherence barriers (AOR = 2.33, 95% CI [1.51, 3.62]) and clinic attendance barriers (AOR = 2.01, 95% CI [1.20, 3.38]) These low-cost strategies can be implemented by local NGOs, making it both scalable and sustainable in this and similar settings.

Indexed as

Quality of LifeAnti-Retroviral AgentsBehavior TherapyChildCommunity-Based Participatory ResearchCounselingHIV InfectionsHumansIndiaMedication AdherenceAnti-Retroviral AgentsART adherence trialCultural relevanceHIVIndiaLMICPLWHViral suppression

Identifiers

PMID31933020
PMCPMC7319881

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.