ArticleBulletin of mathematical biology2020
Coinfection, Altered Vector Infectivity, and Antibody-Dependent Enhancement: The Dengue-Zika Interplay.
Article in Bulletin of mathematical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Mathematical modeling of sequential Dengue-Zika infections: dynamic insights into antibody-dependent enhancement and neutralization effects.Scientific reports · 2026Article
- First record of Zika virus in Yemen.Current research in parasitology & vector-borne diseases · 2026Article
- Identification of multifunctional T-cell peptide epitopes for the development of DNA vaccines against dengue virus.Human vaccines & immunotherapeutics · 2025Article
- Interactions between zoonotic pathogens and infectious disease spread: Why understanding mechanisms and modelling matters more than ever.Biosafety and health · 2025Review
- Exploring Zika's dynamics: A scoping review journey from epidemic to equations through mathematical modelling.Infectious Disease Modelling · 2025Review
- Dengue and zika seropositivity, burden, endemicity, and cocirculation antibodies in Nigeria.Annals of medicine · 2023Article
- Co-infection of dengue and Zika viruses mutually enhances viral replication in the mosquito Aedes aegypti.Parasites & vectors · 2023Article
- Antibody seropositivity and endemicity of chikungunya and Zika viruses in Nigeria.Animal diseases · 2023Article
- System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2.European journal of medicinal chemistry · 2021Article
Corrections and comments
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2 authors.
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Abstract
Although dengue and Zika cocirculation has increased within the past 5 years, very little is known about its epidemiological consequences. To investigate the effect of dengue and Zika cocirculation on the spread of both pathogens, we create a deterministic dengue and Zika coinfection model, the first to incorporate altered infectivity of mosquitoes (due to coinfection). The model also addresses increased infectivity due to antibody-dependent enhancement (ADE) within the human population. Central to our analysis is the derivation and interpretation of the basic reproductive number and invasion reproductive number of both pathogens. In addition, we investigate how model parameters impact the persistence of each disease. Our results identify threshold conditions under which one disease facilitates the spread of the other and show that ADE has a greater impact on disease persistence than altered vector infectivity. This work highlights the importance of ADE and illustrates that while the endemic presence of dengue facilitates the spread of Zika, it is possible for high Zika prevalence to prevent the establishment of dengue.
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