ArticlePediatric nephrology (Berlin, Germany)2020
Grip strength in children with chronic kidney disease.
Article in Pediatric nephrology (Berlin, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Chronic Kidney Disease in Children Prospective Cohort Study (CKiD)
Physical Activity in Adolescents With Chronic Kidney Disease
Who cites it
27 citing papers in PubMed, 40 citations in OpenAlex.
- Physical activity among children and young people with chronic kidney diseases: a scoping review.Pediatric nephrology (Berlin, Germany) · 2026Article
- Assessment of functional capacity in children with chronic kidney disease using various field tests.Pediatric nephrology (Berlin, Germany) · 2026Observational
- Comment on "A study of body composition, muscle strength, and arterial stiffness in adolescents with primary and secondary hypertension".Pediatric nephrology (Berlin, Germany) · 2026Article
- m-Health-based exercise program among children and adolescents with chronic kidney disease: a feasibility study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Identifying Barriers and Facilitators to Physical Activity Participation Among Adolescents With CKD: A Qualitative Study Using Semi-Structured Interviews.Kidney medicine · 2026Article
- Morphofunctional markers to assess disease-related pediatric malnutrition at admission and their association with length of hospital stay.Frontiers in nutrition · 2026Article
- The association between hand grip strength and chronic kidney disease progression: insights from SMP-CKD studies.International urology and nephrology · 2025Observational
- Use of Handgrip Strength as a Health Indicator in Public Sector Workers: A Cross-Sectional Study.Journal of functional morphology and kinesiology · 2025Article
- Balance in children with chronic kidney disease: the relationship between skeletal muscle mass index, fatigue, and physical function.Pediatric nephrology (Berlin, Germany) · 2025Article
- Sugar-sweetened beverages, relative grip strength, and psychological symptoms among rural adolescents in western China: a cross-sectional study.Frontiers in nutrition · 2025Article
- Should we consider sarcopenia in pediatric patients with chronic kidney disease? A preliminary cross-sectional analysis.Pediatric nephrology (Berlin, Germany) · 2024Article
- Paediatric dominant and non-dominant handgrip reference curves and the association with body composition.Annals of human biology · 2024Article
- Hand grip strength as a proposed new vital sign of health: a narrative review of evidences.Journal of health, population, and nutrition · 2024Review
- Association between grip strength and albuminuria in the general United States population: NHANES 2011-2014.Frontiers in public health · 2024Article
- Decreased Muscle Strength in Children With Repaired Tetralogy of Fallot: Relation With Exercise Capacity.Journal of the American Heart Association · 2023Article
- Muscle Wasting among Hospitalized Children: A Narrative Review of the Feasibility and Accuracy of Diagnostic Methods.Children (Basel, Switzerland) · 2023Review
- Muscle strength is reduced in children with pulmonary arterial hypertension.Pulmonary circulation · 2023Article
- Malnutrition Patterns in Children with Chronic Kidney Disease.Life (Basel, Switzerland) · 2023Review
- Assessment of Undernutrition in Pediatric Chronic Kidney Disease - Gaps and Opportunities.Frontiers in pediatrics · 2022Article
- Physical activity and the 'pediatric inactivity triad' in children living with chronic kidney disease: a narrative review.Therapeutic advances in chronic disease · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundThe relationship between muscle strength and chronic kidney disease (CKD) in children is unknown. This study aims to quantify the association between grip strength (GS) and kidney function and to explore factors associated with grip strength in children and adolescents with CKD.
methodsWe included 411 children (699 GS assessments) of the Chronic Kidney Disease in Children (CKiD) study. They were matched by age, sex, and height to a healthy control from the National Health and Nutrition Examination Survey to quantify the relationship between GS and CKD. Linear mixed models were used to identify factors associated with GS among CKD patients.
resultsMedian GS z-score was - 0.72 (IQR - 1.39, 0.11) among CKD patients with CKD stages 2 through 5 having significantly lower GS than CKD stage 1. Compared with healthy controls, CKiD participants had a decreased GS z-score (- 0.53 SD lower, 95% CI - 0.67 to - 0.39) independent of race/ethnicity and body mass index. Factors associated with reduced GS included longer duration of CKD, pre-pubertal status, delayed puberty, neuropsychiatric comorbidities, need of feeding support, need for alkali therapy, and hemoglobin level. Decreased GS was also associated with both a lower frequency and intensity of physical activity.
conclusionsCKD is associated with impaired muscle strength in children independent of growth retardation and BMI. Exposure to CKD for a prolonged time is associated with impaired muscle strength. Potential mediators of the impact of CKD on muscle strength include growth retardation, acidosis, poor nutritional status, and low physical activity. Additional studies are needed to assess the efficacy of interventions targeted at these risk factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.