ArticleJournal of cancer research and clinical oncology2020
Synovial sarcoma disease characteristics and primary tumor sites differ between patient age groups: a report of the Cooperative Weichteilsarkom Studiengruppe (CWS).
Article in Journal of cancer research and clinical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Regional lymph node invasion in pediatric non-rhabdomyosarcoma soft tissue sarcoma: an international cohort study from the International Soft Tissue Sarcoma Consortium.EClinicalMedicine · 2025Article
- Possible Transformation of Pseudotumor to Synovial Sarcoma in a Failed Metal-on-Metal Total Hip Arthroplasty.Arthroplasty today · 2024Article
- Synovial sarcoma: the misdiagnosed sarcoma.EFORT open reviews · 2024Review
- Pre-operative radiotherapy is associated with superior local relapse-free survival in advanced synovial sarcoma.Journal of cancer research and clinical oncology · 2023Article
- Patterns of care and outcomes of 417 patients with METAstatic SYNovial sarcoma (METASYN): real-life data from the French Sarcoma Group (FSG).ESMO open · 2022Article
- The Biology of Synovial Sarcoma: State-of-the-Art and Future Perspectives.Current treatment options in oncology · 2021Review
- Primary renal synovial sarcoma: A case report.Medicine · 2020Article
- TRPA1 Expression in Synovial Sarcoma May Support Neural Origin.Biomolecules · 2020Article
- Heterogeneity of Soft Tissue Sarcomas and Its Implications in Targeted Therapy.Frontiers in oncology · 2020Review
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Authors and funding
26 authors at 15 institutions in 5 countries.
Funding
Abstract
backgroundOlder age is associated with worse outcome in synovial sarcoma (SS) patients. Differences in disease presentation among distinct age groups, however, are currently unknown.
methodsSS patients < 21 years registered in consecutive CWS trials over the period of 1981-2018 were evaluated. Characteristics were analyzed according to age groups using the Fisher's exact test.
resultsThe study population included 432 SS patients. Disease characteristics differed according to age groups of children (0-12 years, n = 176), adolescents (13-16 years, n = 178), and young adults (17-21 years, n = 78). The proportion of invasive tumors (T2) was significantly higher in older patients: children 33%, adolescents 39% and young adults 54%, p = 0.009805. Similarly, the proportion of tumors > 10 cm was higher (13%, 21%, 31%; p = 0.005657) whereas conversely, the proportion of small tumors < 3 cm was lower in older patients (29%, 24%, 6%; p = 0.000104). The presence of metastases at first diagnosis was also highest in older patients (6%, 10%, 21%, p = 0.000963). Notably, the proportion of thigh tumors was higher in older patients (p = 0.04173), whereas the proportion of head-neck tumors was lower in older patients (p = 0.08896).
conclusionsThe rates of large, invasive tumors and the presence of metastases are significantly associated with older patient age. Localization to the thigh is more frequent in older patients. DISCUSSION: The causes for these variations require further exploration.
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