ArticleNature medicine2020
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 741 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
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741citing papers in PubMed, 2 pooled it
64.9field-weighted citation impact, top 1% of its field
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Who cites it
741 citing papers in PubMed, 2 syntheses or guidelines pooled it, 1,163 citations in OpenAlex.
- Association between FDG- and TSPO-PET signals across human and animal studies investigating neurodegenerative conditions: a systematic review.Molecular psychiatry · 2026Pooled it
- Improving reproducibility of differentially expressed genes in single-cell transcriptomic studies of neurodegenerative diseases through meta-analysis.Nature communications · 2025Pooled it
- Periventricular gradient pathology is linked to ependymal reactivity and cell adhesion disruption in multiple sclerosis.Nature neuroscience · 2026Article
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- Metabolic reprogramming of microglia: Effects on development, disease, and therapeutic potential.Neural regeneration research · 2026Article
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- Personalized single-cell transcriptomics reveals molecular diversity in Alzheimer's disease.Nature communications · 2026Article
- Graphene Quantum Dots in Neurodegeneration: Protein Aggregation and the Microglial State as Therapeutic Targets.Nanomaterials (Basel, Switzerland) · 2026Review
- Complement component C4 regulates amyloid pathology and glial reactivity in mouse model of Alzheimer's Disease.bioRxiv : the preprint server for biology · 2026Article
- Priming of CD8Nature neuroscience · 2026Article
- A reproducible three-dimensional model of human brain tissue to investigate physiological and disease-associated microglia phenotypes.Nature neuroscience · 2026Article
- Plasticity of human microglia and brain perivascular macrophages in aging and Alzheimer's disease.Nature genetics · 2026Article
- TMEM59 regulates microglial Aβ phagocytosis in a TREM2-dependent manner and acts as a potential therapeutic target for Aβ amyloidosis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- A meta-refined human Alzheimer's disease-associated gene subset shows partial mouse-model pathway correspondence and limited cross-cohort machine-learning transportability.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Single-cell transcriptomics of human brain disorders.Molecular psychiatry · 2026Review
- Article
- The Substrate-Engine Model of Ferroptosis: Stage-Specific Targeting of Acyl-CoA Synthetase Long-Chain Family Member 4 and 5‑Lipoxygenase in Alzheimer's Disease.ACS pharmacology & translational science · 2026Review
- GPR146 Deficiency Enhances Microglial Phagocytosis and Blood-Brain Barrier-Associated Markers in an Acute Amyloid-β Model.Molecular neurobiology · 2026Article
- Article
- Neuroinflammation in Alzheimer's and Parkinson's diseases: pathogenic mechanisms and therapeutic strategies.Translational neurodegeneration · 2026Review
681 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
25 authors at 10 institutions in 4 countries.
Yingyue ZhouDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-0923-1046
Wilbur M SongDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Prabhakar S AndheyDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Amanda SwainDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-0683-368X
Tyler LevyBluefin Biomedicine, Beverly, MA, USA.
Kelly R MillerNanoString, Seattle, WA, USA.
Pietro L PolianiPathology Unit, Molecular and Translational Medicine Department, University of Brescia, Brescia, Italy.
Manuela CominelliPathology Unit, Molecular and Translational Medicine Department, University of Brescia, Brescia, Italy.
Shikha GroverDepartment of Chemistry & Biochemistry, University of Missouri-St. Louis, St. Louis, MO, USA.
Susan GilfillanDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Marina CellaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Tyler K UllandDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Konstantin ZaitsevDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Akinori MiyashitaDepartment of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan.ORCID http://orcid.org/0000-0003-2508-9649
Takeshi IkeuchiDepartment of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan.ORCID http://orcid.org/0000-0001-8828-8085
Makoto SainouchiDepartment of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
Akiyoshi KakitaDepartment of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
David A BennettRush Alzheimer's Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Julie A SchneiderRush Alzheimer's Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Michael R NicholsDepartment of Chemistry & Biochemistry, University of Missouri-St. Louis, St. Louis, MO, USA.
Sean A BeausoleilBluefin Biomedicine, Beverly, MA, USA.ORCID http://orcid.org/0000-0002-3356-4641
Jason D UlrichDepartment of Neurology, Hope Center for Neurological Disorders, Knight ADRC, Washington University School of Medicine, St. Louis, MO, USA.
David M HoltzmanDepartment of Neurology, Hope Center for Neurological Disorders, Knight ADRC, Washington University School of Medicine, St. Louis, MO, USA.
Maxim N ArtyomovDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. martyomov@wustl.edu.ORCID http://orcid.org/0000-0002-1133-4212
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. mcolonna@wustl.edu.ORCID http://orcid.org/0000-0001-5222-4987
Washington University in St. Louis · USNiigata University · JPBluefin Biomedicine (United States) · USHope Center for Neurological Disorders · USRush University Medical Center · USUniversity of Brescia · ITUniversity of Missouri–St. Louis · USITMO University · RUNanostring Technologies (United States) · USUniversity of Wisconsin–Madison · US
Funding
NATIONAL RESEARCH SERVICE AWARD-MEDICAL SCIENTISTT32GM007200 · NIGMS · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 1985 to 2024
$59.8MSUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI LEURGANS, SUE E. · 1991 to 2020
$49.1MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3MRISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4MNovel Strategies and Mechanisms to Target APOE and Alzheimer's DiseaseRF1AG047644 · NIA · WASHINGTON UNIVERSITY · PI HOLTZMAN, DAVID M., HYMAN, BRADLEY T. · 2019 to 2019
$3.8MTREM2 IN MICROGLIA BIOLOGY AND ALZHEIMER'S DISEASERF1AG051485 · NIA · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2015 to 2021
$3.5MEffect of APOE on CNS Neurons: Role of LRPR01NS090934 · NINDS · WASHINGTON UNIVERSITY · PI HOLTZMAN, DAVID M. · 2014 to 2018
$3.0MTHERAPEUTIC STRATEGIES FOR ALZHEIMER'S DISEASE BASED ON TREM2 BIOLOGYRF1AG059082 · NIA · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2019 to 2019
$2.6MOligomerization State and Function of the NLRP3 InflammasomeR15GM119070 · NIGMS · UNIVERSITY OF MISSOURI-ST. LOUIS · PI NICHOLS, MICHAEL R. · 2016 to 2016
$439kIMPACT OF NOVEL REGULATORS OF TREM2 EXPRESSION ON ALZHEIMER'S DISEASER21AG059176 · NIA · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2018 to 2019
$419kNIA NIH HHS P30 AG010161NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R21 AG059176NIA NIH HHS RF1 AG047644NIA NIH HHS RF1 AG051485NIA NIH HHS RF1 AG059082NIGMS NIH HHS R15 GM119070NIGMS NIH HHS T32 GM007200NINDS NIH HHS R01 NS090934
Abstract
Glia have been implicated in Alzheimer's disease (AD) pathogenesis. Variants of the microglia receptor triggering receptor expressed on myeloid cells 2 (TREM2) increase AD risk, and activation of disease-associated microglia (DAM) is dependent on TREM2 in mouse models of AD. We surveyed gene-expression changes associated with AD pathology and TREM2 in 5XFAD mice and in human AD by single-nucleus RNA sequencing. We confirmed the presence of Trem2-dependent DAM and identified a previously undiscovered Serpina3n
Indexed as
AgedAlzheimer DiseaseAmyloid beta-PeptidesAnimalsAstrocytesAxonsBrainCell NucleusFemaleHumansMaleMembrane GlycoproteinsMice, Inbred C57BLMice, TransgenicMicrogliaMiddle AgedAmyloid beta-PeptidesMembrane GlycoproteinsReceptors, ImmunologicTREM2 protein, humanTrem2 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.