ArticleNature neuroscience2020
Temporally restricted dopaminergic control of reward-conditioned movements.
Article in Nature neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 89 citations in OpenAlex.
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- Phasic dopamine drives conditioned responding beyond its role in learning.bioRxiv : the preprint server for biology · 2026Article
- Memory erasure by dopamine-gated retrospective learning.bioRxiv : the preprint server for biology · 2026Article
- Negative feedback regulation of alcohol ingestion through the FGF21-PVH oxytocin-VTA dopamine system.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Subsecond dopamine fluctuations do not specify the vigor of ongoing actions.Nature neuroscience · 2025Article
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- Dopamine dynamics during stimulus-reward learning in mice can be explained by performance rather than learning.Nature communications · 2025Article
- Flexible value coding in the mesolimbic dopamine system depending on internal water and sodium balance.NPJ science of food · 2025Article
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- Nucleus Accumbens Dopamine Encodes the Trace Period during Appetitive Pavlovian Conditioning.eNeuro · 2025Article
- Hedonic eating is controlled by dopamine neurons that oppose GLP-1R satiety.Science (New York, N.Y.) · 2025Article
- Dopamine activity encodes the changing valence of the same stimulus in conditioned taste aversion paradigms.eLife · 2025Article
- How Dopamine Enables Learning from Aversion.Current opinion in behavioral sciences · 2025Article
- The learning primacy hypothesis of dopamine: reconsidering dopamine's dual functions.Frontiers in cellular neuroscience · 2025Review
- Pre-existing visual responses in a projection-defined dopamine population explain individual learning trajectories.Current biology : CB · 2024Article
- Dopamine builds and reveals reward-associated latent behavioral attractors.Nature communications · 2024Article
- Frustrative Nonreward: Behavior, Circuits, Neurochemistry, and Disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Constraints on the subsecond modulation of striatal dynamics by physiological dopamine signaling.Nature neuroscience · 2024Article
- Explaining dopamine through prediction errors and beyond.Nature neuroscience · 2024Review
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Midbrain dopamine (DA) neurons encode both reward- and movement-related events and are implicated in disorders of reward processing as well as movement. Consequently, disentangling the contribution of DA neurons in reinforcing versus generating movements is challenging and has led to lasting controversy. In this study, we dissociated these functions by parametrically varying the timing of optogenetic manipulations in a Pavlovian conditioning task and examining the influence on anticipatory licking before reward delivery. Inhibiting both ventral tegmental area and substantia nigra pars compacta DA neurons in the post-reward period had a significantly greater behavioral effect than inhibition in the pre-reward period of the task. Furthermore, the contribution of DA neurons to behavior decreased linearly as a function of elapsed time after reward. Together, the results indicate a temporally restricted role of DA neurons primarily related to reinforcing stimulus-reward associations and suggest that directly generating movements is a comparatively less important function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.