Evidence map›Paper›PMID 31932765›Full record

ArticleNature neuroscience2020

A resource for the detailed 3D mapping of white matter pathways in the marmoset brain.

Cirong Liu, Frank Q Ye, John D Newman, Diego Szczupak, Xiaoguang Tian, Cecil Chern-Chyi Yen, Piotr Majka, Daniel Glen, Marcello G P Rosa, David A Leopold and 1 more

Open access · greenAbstract readDataset
In one paragraph

Article in Nature neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 2 pooled it
9.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 2 syntheses or guidelines pooled it, 143 citations in OpenAlex.

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  17. An open access resource for marmoset neuroscientific apparatus.Imaging neuroscience (Cambridge, Mass.) · 2025
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Cirong LiuCerebral Microcirculation Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. cirongliu@gmail.com.ORCID http://orcid.org/0000-0002-7986-4615
Frank Q YeNeurophysiology Imaging Facility, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, and National Eye Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-0459-2184
John D NewmanCerebral Microcirculation Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Diego SzczupakCerebral Microcirculation Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Xiaoguang TianCerebral Microcirculation Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Cecil Chern-Chyi YenCerebral Microcirculation Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Piotr MajkaLaboratory of Neuroinformatics, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Warsaw, Poland.
Daniel GlenScientific and Statistical Computing Core, National Institute of Mental Health, National Institutes of Health (NIMH/NIH), Bethesda, MD, USA.
Marcello G P RosaARC Centre of Excellence for Integrative Brain Function, Clayton, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-6620-6285
David A LeopoldNeurophysiology Imaging Facility, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, and National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Afonso C SilvaCerebral Microcirculation Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. afonso@pitt.edu.ORCID http://orcid.org/0000-0002-6105-7567
National Institutes of Health · USDiscovery Institute · USInstytut Biologii Doświadczalnej im. Marcelego Nenckiego · PL

Funding

Neurophysiology Imaging Facility Core: Functional and Structural MRIZICMH002899 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEOPOLD, DAVID A · 2009 to 2025
$29.1M
Spatial-Temporal Characterization of The Hemodynamic Response to Neural ActivityZIANS003041 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI SILVA, AFONSO · 2009 to 2019
$17.1M
The Neural Underpinnings of Functional MRI NetworksZIAMH002896 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEOPOLD, DAVID A · 2009 to 2025
$13.6M
Spatial-Temporal Characterization of The Hemodynamic Response to Neural ActivityZ01NS003041 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI SILVA, AFONSO · 2007 to 2008
$2.5M
Intramural NIH HHS Z01 NS003041Intramural NIH HHS Z99 NS999999Intramural NIH HHS ZIA NS003041Intramural NIH HHS ZIC MH002899
6 · The paper itself

Abstract

While the fundamental importance of the white matter in supporting neuronal communication is well known, existing publications of primate brains do not feature a detailed description of its complex anatomy. The main barrier to achieving this is that existing primate neuroimaging data have insufficient spatial resolution to resolve white matter pathways fully. Here we present a resource that allows detailed descriptions of white matter structures and trajectories of fiber pathways in the marmoset brain. The resource includes: (1) the highest-resolution diffusion-weighted MRI data available to date, which reveal white matter features not previously described; (2) a comprehensive three-dimensional white matter atlas depicting fiber pathways that were either omitted or misidentified in previous atlases; and (3) comprehensive fiber pathway maps of cortical connections combining diffusion-weighted MRI tractography and neuronal tracing data. The resource, which can be downloaded from marmosetbrainmapping.org, will facilitate studies of brain connectivity and the development of tractography algorithms in the primate brain.

Indexed as

AnimalsBrainBrain MappingCallithrixImaging, Three-DimensionalWhite Matter

Identifiers

PMID31932765
PMCPMC7007400
OpenAlexW2999100257

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.