Evidence map›Paper›PMID 31932742›Full record

Observational studyEuropean journal of clinical nutrition2020

The association of elevated serum ferritin concentration in early pregnancy with gestational diabetes mellitus: a prospective observational study.

Yan Cheng, Tingting Li, Mulan He, Junxiu Liu, Kui Wu, Shuangping Liu, Ziwen Ma, Jingbo Lu, Qingying Zhang, Haidong Cheng

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in European journal of clinical nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yan Cheng *Obstetrics and Gynecology Hospital, Fudan University, 128 Shenyang Road, Shanghai, 200090, PR China.
Tingting Li *Obstetrics and Gynecology Hospital, Fudan University, 128 Shenyang Road, Shanghai, 200090, PR China.
Mulan HeObstetrics and Gynecology Hospital, Fudan University, 128 Shenyang Road, Shanghai, 200090, PR China.
Junxiu LiuObstetrics and Gynecology Hospital, Fudan University, 128 Shenyang Road, Shanghai, 200090, PR China.
Kui WuObstetrics and Gynecology Hospital, Fudan University, 128 Shenyang Road, Shanghai, 200090, PR China.
Shuangping LiuObstetrics and Gynecology Hospital, Fudan University, 128 Shenyang Road, Shanghai, 200090, PR China.
Ziwen MaObstetrics and Gynecology Hospital, Fudan University, 128 Shenyang Road, Shanghai, 200090, PR China.
Jingbo LuObstetrics and Gynecology Hospital, Fudan University, 128 Shenyang Road, Shanghai, 200090, PR China.
Qingying ZhangObstetrics and Gynecology Hospital, Fudan University, 128 Shenyang Road, Shanghai, 200090, PR China. zhanggben@163.com.
Haidong ChengObstetrics and Gynecology Hospital, Fudan University, 128 Shenyang Road, Shanghai, 200090, PR China. hdcheng_2003@163.com.
Obstetrics and Gynecology Hospital of Fudan University · CN

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81471469Science and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission) 14411965600Science and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission) 15411952900
6 · The paper itself

Abstract

BACKGROUND/

objectivesThe results linking body iron stores to the risk of gestational diabetes mellitus (GDM) are conflicting. We aimed to measure the serum ferritin level of women in early pregnancy and evaluate the risk of GDM in a Chinese urban population. SUBJECTS/

methodsIn total, 851 pregnant women between 10 and 20 weeks of gestation took part in the prospective, observational study conducted. The women were divided into four groups by quartiles of serum ferritin levels (Q1-4). Their blood samples were collected and assayed for several biochemical variables at the beginning of the study, and the women were followed up with a 75-g oral glucose tolerance test at 24-28 weeks of gestation.

resultsThe participants had an average serum ferritin concentration of 65.67 μg/L. GDM prevalence within each serum ferritin quartile was 9.4%, 14.6%, 18.8% and 19.3%, respectively, (P = 0.016). The odds ratio for GDM in the ferritin Q2-4 was 1.64 (CI: 0.90-2.99), 2.23 (CI: 1.26-3.96) and 2.31 (CI: 1.30-4.10), compared with Q1, respectively. This association persisted after adjusting for potential confounders factors. In addition, in Q4, pregnant women with a pre-pregnancy body mass index ≥24 kg/m

conclusionsElevated serum ferritin concentrations in early gestation are associated with an increased risk of GDM, especially in pregnant women who have a high baseline iron storage status with no anaemia or who are overweight/obese. Individual iron supplementation should be considered to minimize the risk of GDM.

Indexed as

AdultDiabetes, GestationalFemaleFerritinsGlucose Tolerance TestHumansHyperferritinemiaPregnancyProspective StudiesRisk FactorsFerritins

Identifiers

PMID31932742
OpenAlexW2999357513

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.