ArticleNature chemical biology2020
Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3.
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Article in Nature chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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0cells of the map it votes in
49citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
What it found
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Who cites it
49 citing papers in PubMed, 73 citations in OpenAlex.
- Discovery of a secretedGut microbes · 2026Article
- Design rules for bioorthogonal glycan-based tools.The Biochemical journal · 2026Review
- Research progress in the role and mechanism of GALNT3 in human diseases (Review).Biomedical reports · 2026Review
- GalNAc-T13 maintains neurite architecture and memory retention via O-GalNAc glycosylation of seizure protein 6.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Decoding the complex substrate specificities of GalNAc-Ts.Glycobiology · 2025Review
- Altered O-glycosylation of βThe FEBS journal · 2025Article
- GALNT3 in Ischemia-Reperfusion Injury of the Kidney.Journal of the American Society of Nephrology : JASN · 2025Article
- A Novel Pathogenic Variant in Fibroblast Growth Factor 23 outside the Furin-Recognizing RXXR Motif in an Autosomal Dominant Hypophosphatemic Rickets Patient.Hormone research in paediatrics · 2025Article
- Rational Design of Dual-Domain Binding Inhibitors forJACS Au · 2024Article
- A GALNT3 mutation causing Hyperphosphatemic familial Tumoral calcinosis.Molecular genetics and metabolism reports · 2024Article
- O-glycosylation of SARS-CoV-2 spike protein by host O-glycosyltransferase strengthens its trimeric structure.Acta biochimica et biophysica Sinica · 2024Article
- Sequential glycosylations at the multibasic cleavage site of SARS-CoV-2 spike protein regulate viral activity.Nature communications · 2024Article
- A Toxoplasma gondii O-glycosyltransferase that modulates bradyzoite cyst wall rigidity is distinct from host homologues.Nature communications · 2024Article
- An unusual dual sugar-binding lectin domain controls the substrate specificity of a mucin-type O-glycosyltransferase.Science advances · 2024Article
- Significance of Premature Vertebral Mineralization in Zebrafish Models in Mechanistic and Pharmaceutical Research on Hereditary Multisystem Diseases.Biomolecules · 2023Review
- Polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) isozyme surface charge governs charge substrate preferences to modulate mucin type O-glycosylation.Glycobiology · 2023Article
- Elderly-onset calcinosis of hyperphosphataemic familial tumoural calcinosis/hyperostosis-hyperphosphataemia syndrome: the role of comorbid scleroderma.Endocrinology, diabetes & metabolism case reports · 2023Article
- 1,25-Dihydroxyvitamin D3 regulates furin-mediated FGF23 cleavage.JCI insight · 2023Article
- Bone-derived C-terminal FGF23 cleaved peptides increase iron availability in acute inflammation.Blood · 2023Article
- Short report galectins use N-glycans of FGFs to capture growth factors at the cell surface and fine-tune their signaling.Cell communication and signaling : CCS · 2023Article
Corrections and comments
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Authors and funding
18 authors at 9 institutions in 6 countries.
Matilde de Las Rivas *BIFI, University of Zaragoza, Mariano Esquillor s/n, Campus Rio Ebro, Edificio I+D, Zaragoza, Spain.
Earnest James Paul Daniel *Department of Biochemistry, Case Western Reserve University, Cleveland, OH, USA.
Yoshiki Narimatsu *Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, School of Dentistry, University of Copenhagen, Copenhagen, Denmark.
Ismael Compañón *Departamento de Química, Universidad de La Rioja, Centro de Investigación en Síntesis Química, Logroño, Spain.
Kentaro KatoCopenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, School of Dentistry, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-4890-567X
Pablo HermosillaLaboratorio de Microscopías Avanzadas, Instituto de Nanociencia de Aragón, Universidad de Zaragoza, Zaragoza, Spain.
Aurélien ThureauSwing Beamline, Synchrotron SOLEIL, Gif sur Yvette, France.
Laura Ceballos-LaitaBIFI, University of Zaragoza, Mariano Esquillor s/n, Campus Rio Ebro, Edificio I+D, Zaragoza, Spain.
Helena CoelhoUCIBIO, REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade de Nova de Lisboa, Caparica, Portugal.ORCID http://orcid.org/0000-0003-1992-8557
Pau BernadóCentre de Biochimie Structurale. INSERM, CNRS, Université de Montpellier, Montpellier, France.
Filipa MarceloUCIBIO, REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade de Nova de Lisboa, Caparica, Portugal.
Lars HansenCopenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, School of Dentistry, University of Copenhagen, Copenhagen, Denmark.
Ryota MaedaDepartment of Hematology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Anabel LostaoLaboratorio de Microscopías Avanzadas, Instituto de Nanociencia de Aragón, Universidad de Zaragoza, Zaragoza, Spain.ORCID http://orcid.org/0000-0001-7460-5916
Francisco CorzanaDepartamento de Química, Universidad de La Rioja, Centro de Investigación en Síntesis Química, Logroño, Spain.ORCID http://orcid.org/0000-0001-5597-8127
Henrik ClausenCopenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, School of Dentistry, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-0915-5055
Thomas A GerkenDepartment of Biochemistry, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-7919-7613
Ramon Hurtado-GuerreroBIFI, University of Zaragoza, Mariano Esquillor s/n, Campus Rio Ebro, Edificio I+D, Zaragoza, Spain. rhurtado@bifi.es.ORCID http://orcid.org/0000-0002-3122-9401
University of Copenhagen · DKUniversidad de Zaragoza · ESCase Western Reserve University · USUniversidad de La Rioja · ESCentre National de la Recherche Scientifique · FRCIC bioGUNE · ESKyoto University · JPRede de Química e Tecnologia · PTSynchrotron soleil · FR
Funding
Initiation and Regulation of Mucin-Type O-GlycosylationR01GM113534 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI GERKEN, THOMAS A · 2018 to 2023
$1.6MInitiation and regulation of mucin-type O-glycosylationU01GM113534 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI GERKEN, THOMAS A · 2015 to 2017
$1.0MNIGMS NIH HHS R01 GM113534NIGMS NIH HHS U01 GM113534
Abstract
Polypeptide GalNAc-transferase T3 (GalNAc-T3) regulates fibroblast growth factor 23 (FGF23) by O-glycosylating Thr178 in a furin proprotein processing motif RHT
Indexed as
AnimalsCHO CellsCricetulusFibroblast Growth Factor-23Fibroblast Growth FactorsGlycopeptidesGlycosylationHumansIsoenzymesLectinsN-AcetylgalactosaminyltransferasesPolypeptide N-acetylgalactosaminyltransferaseThreonineFGF23 protein, humanFibroblast Growth Factor-23Fibroblast Growth FactorsGlycopeptidesIsoenzymesLectinsN-AcetylgalactosaminyltransferasesPolypeptide N-acetylgalactosaminyltransferaseThreonine
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.