Evidence map›Paper›PMID 31932712›Full record

ArticleNature microbiology2020

Staphylococcus aureus cell growth and division are regulated by an amidase that trims peptides from uncrosslinked peptidoglycan.

Truc Do, Kaitlin Schaefer, Ace George Santiago, Kathryn A Coe, Pedro B Fernandes, Daniel Kahne, Mariana G Pinho, Suzanne Walker

Open access · greenAbstract read
In one paragraph

Article in Nature microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
  2. Article
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  4. A conserved hub protein required for peptidoglycan remodeling and cell division inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Article
  7. SpbR controls lipoteichoic acid length by directly inhibiting signal peptidase SpsB inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Article
  10. The Secondary Resistome of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2025
    Article
  11. Article
  12. Article
  13. Bacterial cell volume regulation and the importance of cyclic di-AMP.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Truc DoDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.
Kaitlin SchaeferDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.
Ace George SantiagoDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.
Kathryn A CoeDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6806-7314
Pedro B FernandesBacterial Cell Biology, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.
Daniel KahneDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Mariana G PinhoBacterial Cell Biology, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.ORCID http://orcid.org/0000-0002-7132-8842
Suzanne WalkerDepartment of Microbiology, Harvard Medical School, Boston, MA, USA. suzanne_walker@hms.harvard.edu.ORCID http://orcid.org/0000-0002-0545-914X
Harvard University · USUniversidade Nova de Lisboa · PT

Funding

Technical Mother Machine CoreP01AI083214 · NIAID · SCHEPENS EYE RESEARCH INSTITUTE · PI Michael S Gilmore · 2009 to 2026
$39.4M
Mechanism and Inhibition of Enzymes that Assemble Bacterial Cell WallR01GM076710 · NIGMS · HARVARD MEDICAL SCHOOL · PI WALKER, SUZANNE · 2007 to 2019
$5.9M
Identifying and validating new antibiotic targets in cell wall synthesis pathwaysR01AI099144 · NIAID · HARVARD MEDICAL SCHOOL · PI BERNHARDT, THOMAS G, WALKER, SUZANNE · 2012 to 2016
$4.3M
Release of Extracellular DNA during Biofilm Formation in Staphylococcus aureusR01AI139011 · NIAID · HARVARD UNIVERSITY · PI KAHNE, DANIEL, LOSICK, RICHARD MARC · 2018 to 2022
$3.2M
European Research Council 771709NIAID NIH HHS P01 AI083214NIAID NIH HHS R01 AI099144NIAID NIH HHS R01 AI139011NIGMS NIH HHS R01 GM076710
6 · The paper itself

Abstract

Bacteria are protected by a polymer of peptidoglycan that serves as an exoskeleton

Indexed as

Bacterial ProteinsCell CycleCell DivisionGene DeletionGenes, BacterialModels, BiologicalMutationN-Acetylmuramoyl-L-alanine AmidasePeptidoglycanRecombinant ProteinsStaphylococcus aureusSubstrate SpecificityBacterial ProteinsLytH protein, Staphylococcus aureusN-Acetylmuramoyl-L-alanine AmidasePeptidoglycanRecombinant Proteins

Identifiers

PMID31932712
PMCPMC7046134
OpenAlexW2999935025

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.