Evidence map›Paper›PMID 31932669›Full record

ArticleNature materials2020

Ordered three-dimensional nanomaterials using DNA-prescribed and valence-controlled material voxels.

Ye Tian, Julien R Lhermitte, Lin Bai, Thi Vo, Huolin L Xin, Huilin Li, Ruipeng Li, Masafumi Fukuto, Kevin G Yager, Jason S Kahn and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed.

  1. Article
  2. Hierarchical Assembly of Multilayer Core-Shell DNA Origami Crystals.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Crystallographic Study of DNA T-Junction via Crystal Engineering.Angewandte Chemie (International ed. in English) · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Magnetic decoupling as a proofreading strategy for high-yield, time-efficient microscale self-assembly.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Article
  14. Article
  15. Designing the Self-Assembly of Disordered Materials Via Color Frustration.Advanced materials (Deerfield Beach, Fla.) · 2025
    Article
  16. Article
  17. Engineering Liquid Hierarchical Materials with DNA-Programmed Spherical Nucleic Acids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  18. Article
  19. Article
  20. Article

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Ye TianCenter for Functional Nanomaterials, Brookhaven National Laboratory, Upton, NY, USA.
Julien R LhermitteCenter for Functional Nanomaterials, Brookhaven National Laboratory, Upton, NY, USA.
Lin BaiVan Andel Institute, Grand Rapids, MI, USA.ORCID http://orcid.org/0000-0002-7535-7819
Thi VoDepartment of Chemical Engineering, Columbia University, New York, NY, USA.
Huolin L XinCenter for Functional Nanomaterials, Brookhaven National Laboratory, Upton, NY, USA.ORCID http://orcid.org/0000-0002-6521-868X
Huilin LiVan Andel Institute, Grand Rapids, MI, USA.ORCID http://orcid.org/0000-0001-8085-8928
Ruipeng LiNational Synchrotron Light Source II, Brookhaven National Laboratory, Upton, NY, USA.
Masafumi FukutoNational Synchrotron Light Source II, Brookhaven National Laboratory, Upton, NY, USA.
Kevin G YagerCenter for Functional Nanomaterials, Brookhaven National Laboratory, Upton, NY, USA.
Jason S KahnDepartment of Chemical Engineering, Columbia University, New York, NY, USA.
Yan XiongDepartment of Chemical Engineering, Columbia University, New York, NY, USA.
Brian MinevichDepartment of Chemical Engineering, Columbia University, New York, NY, USA.
Sanat K KumarDepartment of Chemical Engineering, Columbia University, New York, NY, USA.
Oleg GangCenter for Functional Nanomaterials, Brookhaven National Laboratory, Upton, NY, USA. og2226@columbia.edu.ORCID http://orcid.org/0000-0001-5534-3121

Funding

Structural mechanism of DNA replicationR35GM131754 · NIGMS · VAN ANDEL RESEARCH INSTITUTE · PI Huilin Li · 2019 to 2026
$6.0M
6 · The paper itself

Abstract

The ability to organize nanoscale objects into well-defined three-dimensional (3D) arrays can translate advances in nanoscale synthesis into targeted material fabrication. Despite successes in nanoparticle assembly, most extant methods are system specific and not fully compatible with biomolecules. Here, we report a platform for creating distinct 3D ordered arrays from different nanomaterials using DNA-prescribed and valence-controlled material voxels. These material voxels consist of 3D DNA frames that integrate nano-objects within their scaffold, thus enabling the object's valence and coordination to be determined by the frame's vertices, which can bind to each other through hybridization. Such DNA material voxels define the lattice symmetry through the spatially prescribed valence decoupling the 3D assembly process from the nature of the nanocomponents, such as their intrinsic properties and shapes. We show this by assembling metallic and semiconductor nanoparticles and also protein superlattices. We support the technological potential of such an assembly approach by fabricating light-emitting 3D arrays with diffraction-limited spectral purity and 3D enzymatic arrays with increased activity.

Indexed as

Chemical EngineeringCrystallizationDNA, Single-StrandedMolecular StructureNanostructuresDNA, Single-Stranded

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.