Article in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
Hui YanDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.
Maria FernandezDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.ORCID 0000-0002-4820-821X
Jingwei WangDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.
Shuai WuDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.ORCID 0000-0003-1818-0831
Rui WangDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.
Zheng LouDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.
Justin B MoroneyDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.ORCID 0000-0002-3656-1892
Carlos E RiveraDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.ORCID 0000-0001-9052-557X
Julia R TaylorDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.ORCID 0000-0002-7549-0812
Huoqun GanDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.
Hong ZanDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.ORCID 0000-0002-2873-7034
Dmytro KolvaskyyGreehey Children's Cancer Research Institute, University of Texas Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229; and.
Dongfang LiuDepartment of Pathology, Immunology and Laboratory Medicine, New Jersey Medical School, Rutgers University, Newark, NJ 07103.
Paolo CasaliDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229; pcasali@uthscsa.edu xuz3@uthscsa.edu.ORCID 0000-0002-8982-5177
Zhenming XuDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229; pcasali@uthscsa.edu xuz3@uthscsa.edu.ORCID 0000-0002-5822-0570
The University of Texas Health Science Center at San Antonio · USRutgers, The State University of New Jersey · US
Funding
TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Robin Jean Leach · 1991 to 2026
$59.1M
Institute for Integration of Medicine & Science: A Partnership to Improve HealthUL1TR001120 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, HARGREAVES, KENNETH M · 2013 to 2017
$16.5M
Institutional Research Training GrantT32DE014318 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Kenneth M Hargreaves · 2002 to 2026
$12.1M
Intrinsic B cell epigenetic regulation of antibody and autoantibody responses by Sirt1R01AI105813 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CASALI, PAOLO · 2014 to 2023
$4.5M
Somatic hypermutation and class switching in autoimmunityR01AI079705 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CASALI, PAOLO · 2010 to 2019
$4.1M
Graduate Research in Immunology Program (GRIP): To train graduate students for successful careers in academia, industry and governmentT32AI138944 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ZHONG, GUANGMING · 2018 to 2022
$561k
B cells as a major source of IL-27 cytokine in antibody responses and anti-viral immunityR21AI135599 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI XU, ZHENMING · 2018 to 2019
$419k
Role of intracellular membrane signalosomes in B cell NF-kappaB activationR21AI131034 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI XU, ZHENMING · 2018 to 2019
$419k
Rab7 and NF-kappaB in B cell activation and dysregulationR21AI124172 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI XU, ZHENMING · 2016 to 2017
$413k
Molecular mechanisms in the generation of autoantibodies and lupusR56AI079705 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI CASALI, PAOLO · 2008 to 2008
$381k
Epigenetic downregulation of the antibody response and inhibition of autoimmunityR56AI105813 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI CASALI, PAOLO · 2013 to 2013
Upon activation by CD40 or TLR signaling, B lymphocytes activate NF-κB to induce activation-induced cytidine deaminase and, therefore, Ig class switch DNA recombination, as central to the maturation of the Ab and autoantibody responses. In this study, we show that NF-κB activation is boosted by colocalization of engaged immune receptors, such as CD40, with RAB7 small GTPase on mature endosomes, in addition to signals emanating from the receptors localized on the plasma membrane, in mouse B cells. In mature endosomes, RAB7 directly interacts with TRAF6 E3 ubiquitin ligase, which catalyzes K63 polyubiquitination for NF-κB activation. RAB7 overexpression in
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
B Cell Endosomal RAB7 Promotes TRAF6 K63 Polyubiquitination and NF-κB Activation for Antibody Class-Switching. · full record | OpenQuestion