Evidence map›Paper›PMID 31932491›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2020

Cannabinoids Promote Progression of HPV-Positive Head and Neck Squamous Cell Carcinoma via p38 MAPK Activation.

Chao Liu, Sayed H Sadat, Koji Ebisumoto, Akihiro Sakai, Bharat A Panuganti, Shuling Ren, Yusuke Goto, Sunny Haft, Takahito Fukusumi, Mizuo Ando and 9 more

Open access · greenAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
9.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Review
  4. Cancer-associated fibroblast-derived SEMA3C facilitates colorectal cancer liver metastasis via NRP2-mediated MAPK activation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  10. Role of Cannabinoids in Oral Cancer.International journal of molecular sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 2 countries.

Chao LiuMoores Cancer Center, University of California San Diego, La Jolla, California.
Sayed H SadatMoores Cancer Center, University of California San Diego, La Jolla, California.
Koji EbisumotoMoores Cancer Center, University of California San Diego, La Jolla, California.
Akihiro SakaiMoores Cancer Center, University of California San Diego, La Jolla, California.ORCID 0000-0002-1068-5061
Bharat A PanugantiDivision of Otolaryngology, Head and Neck Surgery, Department of Surgery, University of California San Diego, La Jolla, California.
Shuling RenMoores Cancer Center, University of California San Diego, La Jolla, California.
Yusuke GotoMoores Cancer Center, University of California San Diego, La Jolla, California.
Sunny HaftMoores Cancer Center, University of California San Diego, La Jolla, California.
Takahito FukusumiMoores Cancer Center, University of California San Diego, La Jolla, California.
Mizuo AndoMoores Cancer Center, University of California San Diego, La Jolla, California.ORCID 0000-0002-0754-2545
Yuki SaitoMoores Cancer Center, University of California San Diego, La Jolla, California.
Theresa GuoDepartment of Otolaryngology, Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Pablo TamayoMoores Cancer Center, University of California San Diego, La Jolla, California.
Huwate YeernaMoores Cancer Center, University of California San Diego, La Jolla, California.
William KimMoores Cancer Center, University of California San Diego, La Jolla, California.
Jacqueline HubbardDepartment of Pathology, University of California San Diego, La Jolla, California.
Andrew B SharabiDepartment of Radiation Medicine and Applied Science, University of California San Diego, La Jolla, California.
J Silvio GutkindMoores Cancer Center, University of California San Diego, La Jolla, California.
Joseph A CalifanoMoores Cancer Center, University of California San Diego, La Jolla, California. jcalifano@ucsd.edu.
University of California San Diego · USCentral South University · CNJohns Hopkins University · US

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jesse Nodora · 1985 to 2026
$124.9M
Knowledge-based Gene Expression Analysis for Biomedical and Cancer ResearchR01CA121941 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MESIROV, JILL P. · 2006 to 2016
$5.1M
A Rational Systematic Approach to Find Combinations of Pharmacologic and Immune Therapies that Target Identifiable Oncogenic StatesU01CA217885 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI COHEN, EZRA, KAUFMAN, DAN S. · 2017 to 2021
$5.1M
Stimulating Neo-Antigen Specific T Cell Responses in Head and Neck CancersU01DE028227 · NIDCR · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI GUTKIND, JORGE SILVIO, RAO, ANJANA · 2018 to 2022
$4.6M
GenePattern and GenePattern Notebook: Integrative 'Omic Analysis for Cancer ResearchU24CA248457 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MESIROV, JILL P., TAMAYO, PABLO · 2020 to 2024
$4.6M
Next-generation Functional Genetic Screening of Un-screenable TraitsR01HG009285 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALI, PRASHANT, TAMAYO, PABLO · 2017 to 2020
$4.2M
Supporting and evolving Gene Set Enrichment Analysis and the Molecular Signatures Database for cancer researchU24CA220341 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MESIROV, JILL P., TAMAYO, PABLO · 2018 to 2022
$3.4M
GenePattern Notebooks for Cancer ResearchU24CA194107 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MESIROV, JILL P. · 2015 to 2019
$2.8M
Targeting Drug-Resistant Cancer Stem Cell Niches of Gastrointestinal Stromal TumorR01CA226803 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SICKLICK, JASON KEITH · 2019 to 2023
$2.1M
Epigenetic Biomarker Discovery in HPV Related HNSCCR01DE023347 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CALIFANO, JOSEPH A · 2013 to 2017
$1.9M
NCI NIH HHS P30 CA023100NCI NIH HHS R01 CA121941NCI NIH HHS R01 CA226803NCI NIH HHS U01 CA217885NCI NIH HHS U24 CA194107NCI NIH HHS U24 CA220341NCI NIH HHS U24 CA248457NHGRI NIH HHS R01 HG009285NIDCR NIH HHS R01 DE023347NIDCR NIH HHS U01 DE028227
6 · The paper itself

Abstract

purposeHuman papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) is associated with daily marijuana use and is also increasing in parallel with increased marijuana use in the United States. Our study is designed to define the interaction between cannabinoids and HPV-positive HNSCC. EXPERIMENTAL

designThe expression of cannabinoid receptors

resultsIn TCGA cohort, the expression of

conclusionsCannabinoids can promote progression of HPV-positive HNSCC through p38 MAPK pathway activation.

Indexed as

AnimalsApoptosisCannabinoidsCell MovementCell ProliferationFemaleHead and Neck NeoplasmsHumansMiceMice, Nudep38 Mitogen-Activated Protein KinasesPapillomaviridaePapillomavirus InfectionsPrognosisReceptors, CannabinoidSquamous Cell Carcinoma of Head and NeckCannabinoidsp38 Mitogen-Activated Protein KinasesReceptors, Cannabinoid

Identifiers

PMID31932491
PMCPMC7538010
OpenAlexW2999717878

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.