Evidence map›Paper›PMID 31932482›Full record

ArticleMolecular and cellular biology2020

ZFP628 Is a TAF4b-Interacting Transcription Factor Required for Mouse Spermiogenesis.

Eric A Gustafson, Kimberly A Seymour, Kirsten Sigrist, Dirk G D E Rooij, Richard N Freiman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Eric A GustafsonBrown University, Department of Molecular and Cell Biology and Biochemistry, Providence, Rhode Island, USA.
Kimberly A SeymourBrown University, Department of Molecular and Cell Biology and Biochemistry, Providence, Rhode Island, USA.
Kirsten SigristBrown University, Department of Molecular and Cell Biology and Biochemistry, Providence, Rhode Island, USA.
Dirk G D E RooijReproductive Biology Group, Division of Developmental Biology, Department of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Richard N FreimanBrown University, Department of Molecular and Cell Biology and Biochemistry, Providence, Rhode Island, USA Richard_Freiman@Brown.edu.
Brown University · USUtrecht University · NL

Funding

Ovarian-specific transcription networks regulated by the TFIID subunit TAF4bR01HD065445 · NICHD · BROWN UNIVERSITY · PI FREIMAN, RICHARD NEIL · 2010 to 2014
$1.6M
The Role of TAF4b in Spermatogonial Stem Cell Maintenance and Self-RenewalF32HD077986 · NICHD · BROWN UNIVERSITY · PI GUSTAFSON, ERIC · 2013 to 2015
$180k
NICHD NIH HHS F32 HD077986NICHD NIH HHS R01 HD065445
6 · The paper itself

Abstract

TAF4b is a subunit of the TFIID complex that is highly expressed in the ovary and testis and required for mouse fertility. TAF4b-deficient male mice undergo a complex series of developmental defects that result in the inability to maintain long-term spermatogenesis. To decipher the transcriptional mechanisms upon which TAF4b functions in spermatogenesis, we used two-hybrid screening to identify a novel TAF4b-interacting transcriptional cofactor, ZFP628. Deletion analysis of both proteins reveals discrete and novel domains of ZFP628 and TAF4b protein that function to bridge their direct interaction

Indexed as

AnimalsApoptosisCell LineChromosomal Proteins, Non-HistoneCRISPR-Cas SystemsDNA-Binding ProteinsFemaleHEK293 CellsHumansInfertility, MaleMaleMiceMice, Inbred C57BLMice, KnockoutOvaryProtaminesChromosomal Proteins, Non-HistoneDNA-Binding ProteinsPrm1 protein, mouseprotamine 2Protaminesspermatid transition proteinsTaf4b protein, mouseTATA-Binding Protein Associated FactorsTnp2 protein, mouseTranscription FactorsTranscription Factor TFIIDZfp628 protein, mousemale fertilitymeiosisspermatogenesisspermiogenesisTAF4bTFIIDtranscriptionZFP628

Identifiers

PMID31932482
PMCPMC7076252
OpenAlexW3000110367

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.