Evidence map›Paper›PMID 31932443›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

LINGO1 is a regulatory subunit of large conductance, Ca

Srikanth Dudem, Roddy J Large, Shruti Kulkarni, Heather McClafferty, Irina G Tikhonova, Gerard P Sergeant, Keith D Thornbury, Michael J Shipston, Brian A Perrino, Mark A Hollywood

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 67 citations in OpenAlex.

  1. Review
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  5. Article
  6. Tuning the gate and the gear: The LRRC26 (γ1) subunit modulates intrinsic gating and voltage-sensor coupling of the BK channel.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
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  12. Tuning the gate and the gear: The LRRC26 (bioRxiv : the preprint server for biology · 2025
    Article
  13. Article
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  15. Andrology · 2025
    Review
  16. Article
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  19. Involvement of KAntioxidants (Basel, Switzerland) · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Srikanth DudemSmooth Muscle Research Centre, Dundalk Institute of Technology, Louth A81 K584, Ireland.
Roddy J LargeSmooth Muscle Research Centre, Dundalk Institute of Technology, Louth A81 K584, Ireland.
Shruti KulkarniSmooth Muscle Research Centre, Dundalk Institute of Technology, Louth A81 K584, Ireland.
Heather McClaffertyCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH8 9XD, Scotland.
Irina G TikhonovaSchool of Pharmacy, Queen's University of Belfast, Belfast BT9 7BL, Northern Ireland.
Gerard P SergeantSmooth Muscle Research Centre, Dundalk Institute of Technology, Louth A81 K584, Ireland.
Keith D ThornburySmooth Muscle Research Centre, Dundalk Institute of Technology, Louth A81 K584, Ireland.
Michael J ShipstonCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH8 9XD, Scotland.ORCID 0000-0001-7544-582X
Brian A PerrinoDepartment of Physiology and Cell Biology, Reno School of Medicine, University of Nevada, Reno, NV 89557.
Mark A HollywoodSmooth Muscle Research Centre, Dundalk Institute of Technology, Louth A81 K584, Ireland; mark.hollywood@dkit.ie.
Dundalk Institute of Technology · IEUniversity of Edinburgh · GBQueen's University Belfast · GBUniversity of Nevada, Reno · US

Funding

British Heart Foundation PG/12/57/29782Medical Research Council MR/R010668/1
6 · The paper itself

Abstract

LINGO1 is a transmembrane protein that is up-regulated in the cerebellum of patients with Parkinson's disease (PD) and Essential Tremor (ET). Patients with additional copies of the LINGO1 gene also present with tremor. Pharmacological or genetic ablation of large conductance Ca

Indexed as

Amino Acid SequenceCell LineCerebellumHumansLarge-Conductance Calcium-Activated Potassium ChannelsMembrane ProteinsNerve Tissue ProteinsProtein BindingLarge-Conductance Calcium-Activated Potassium ChannelsLINGO1 protein, humanMembrane ProteinsNerve Tissue Proteinsaccessory subunitsBK channelsleucine-rich repeat containing proteinsLINGO1Parkinson’s disease

Identifiers

PMID31932443
PMCPMC6994976
OpenAlexW3000122400

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.