Evidence map›Paper›PMID 31932432›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

The nutrient sensor OGT regulates Hipk stability and tumorigenic-like activities in

Kenneth Kin Lam Wong, Ta-Wei Liu, Jessica M Parker, Donald A R Sinclair, Yi-Yun Chen, Kay-Hooi Khoo, David J Vocadlo, Esther M Verheyen

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. HIPK2 in the physiology of nervous system and its implications in neurological disorders.Biochimica et biophysica acta. Molecular cell research · 2023
    Review
  8. Review
  9. The role of O-GlcNAcylation in development.Development (Cambridge, England) · 2023
    Article
  10. Article
  11. Embracing complexity in Drosophila cancer models.Disease models & mechanisms · 2022
    Article
  12. Article
  13. Review
  14. Review
  15. Hyperpolarized mitochondria accumulate inJournal of cell science · 2020
    Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Kenneth Kin Lam WongDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
Ta-Wei LiuDepartment of Chemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
Jessica M ParkerDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
Donald A R SinclairDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
Yi-Yun ChenInstitute of Biological Chemistry, Academia Sinica, 115 Taipei, Taiwan.
Kay-Hooi KhooInstitute of Biological Chemistry, Academia Sinica, 115 Taipei, Taiwan.
David J VocadloDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.ORCID 0000-0001-6897-5558
Esther M VerheyenDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada; everheye@sfu.ca.ORCID 0000-0002-9795-5094
Simon Fraser University · CAInstitute of Biological Chemistry, Academia Sinica · TW

Funding

CIHR PJT-148732CIHR PJT-156204
6 · The paper itself

Abstract

Environmental cues such as nutrients alter cellular behaviors by acting on a wide array of molecular sensors inside cells. Of emerging interest is the link observed between effects of dietary sugars on cancer proliferation. Here, we identify the requirements of hexosamine biosynthetic pathway (HBP) and

Indexed as

AcetylglucosamineAnimalsCarcinogenesisCarrier ProteinsCell ProliferationCells, CulturedDrosophila melanogasterDrosophila ProteinsFibroblastsGlucoseHEK293 CellsHumansMCF-7 CellsMiceN-AcetylglucosaminyltransferasesPhosphorylationAcetylglucosamineCarrier ProteinsDrosophila ProteinsGlucoseHIPK2 protein, humanHIPK protein, DrosophilaN-AcetylglucosaminyltransferasesO-GlcNAc transferaseProtein KinasesProtein Serine-Threonine KinasesSweetening AgentsDrosophilaHipkO-GlcNAcOGTtumorigenesis

Identifiers

PMID31932432
PMCPMC6994980
OpenAlexW2998869223

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.