Trial reportProceedings of the National Academy of Sciences of the United States of America2020
2 registry-linked trialsOpen access · hybridAbstract readClinical Trial
In one paragraph
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT05623059 phase1 / phase2completednot on this mapstarted 2023, after this paper: background citation
Phase IIa Clinical Trial to Evaluate Pharmacokinetics and Safety of Slow Release DHEA
NCT07179952 phase2not yet recruitingnot on this mapstarted 2027, after this paper: background citation
A Study to Evaluate Efficacy and Safety of Slow Release DHEA
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Sex-biased Gene Expression Underlies Immune Dysfunction in Asthma.American journal of respiratory cell and molecular biology · 2025Pooled it
- Serendipity, steroids and science.The Journal of steroid biochemistry and molecular biology · 2026Review
- Hidden immune memory niches in inflammatory skin diseases.bioRxiv : the preprint server for biology · 2026Article
- Sex Differences in Asthma Pathogenesis.Immunological reviews · 2026Review
- Asthma Inception: Epidemiologic Risk Factors and Natural History Across the Life Course.American journal of respiratory and critical care medicine · 2024Review
- Chromatin accessibility and pioneer factor FOXA1 restrict glucocorticoid receptor action in prostate cancer.Nucleic acids research · 2024Article
- Sex hormones and allergies: exploring the gender differences in immune responses.Frontiers in allergy · 2024Review
- Glucocorticoid receptor action in prostate cancer: the role of transcription factor crosstalk.Frontiers in endocrinology · 2024Review
- Aging-Related Mechanisms Contribute to Corticosteroid Insensitivity in Elderly Asthma.International journal of molecular sciences · 2023Review
- The Influence of Sex Hormones and X Chromosome in Immune Responses.Current topics in microbiology and immunology · 2023Review
- 5-Hydroxyeicosatetraenoic Acid Controls Androgen Reduction in Diverse Types of Human Epithelial Cells.Endocrinology · 2022Article
- Urinary total conjugated 3-bromotyrosine, asthma severity, and exacerbation risk.American journal of physiology. Lung cellular and molecular physiology · 2022Article
- Association Between Adrenal-Restrictive HSD3B1 Inheritance and Hormone-Independent Subtypes of Endometrial and Breast Cancer.JNCI cancer spectrum · 2022Article
- Inheritance of a common androgen synthesis variant allele is associated with female COVID susceptibility in UK Biobank.European journal of endocrinology · 2022Article
- Association Between Asthma and Reduced Androgen Receptor Expression in Airways.Journal of the Endocrine Society · 2022Article
- Androgen receptor signaling promotes Treg suppressive function during allergic airway inflammation.The Journal of clinical investigation · 2022Article
- Article
- Understanding sex differences in the allergic immune response to food.AIMS allergy and immunology · 2022Article
- Sex and gender in asthma.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Adrenal-permissive HSD3B1 genetic inheritance and risk of estrogen-driven postmenopausal breast cancer.JCI insight · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors at 17 institutions in 2 countries.
Joe ZeinLerner Research Institute and the Respiratory Institute, Cleveland Clinic, Cleveland, OH 44195.
Benjamin GastonHerman Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202.
Peter BazeleyLerner Research Institute and the Respiratory Institute, Cleveland Clinic, Cleveland, OH 44195.
Mark D DeBoerDepartment of Pediatrics, University of Virginia, Charlottesville, VA 22904.
Robert P IgoDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106.
Eugene R BleeckerDepartment of Medicine, University of Arizona Health Sciences, Tucson, AZ 85721.
Deborah MeyersDepartment of Medicine, University of Arizona Health Sciences, Tucson, AZ 85721.
Suzy ComhairLerner Research Institute and the Respiratory Institute, Cleveland Clinic, Cleveland, OH 44195.
Nadzeya V MarozkinaDepartment of Pediatrics, Rainbow Babies and Children's Hospital, and Case Western Reserve University, Cleveland, OH 44106.ORCID 0000-0002-1692-8634
Calvin CottonDepartment of Pediatrics, Rainbow Babies and Children's Hospital, and Case Western Reserve University, Cleveland, OH 44106.
Mona PatelLerner Research Institute and the Respiratory Institute, Cleveland Clinic, Cleveland, OH 44195.
Mohammad AlyamaniLerner Research Institute and the Respiratory Institute, Cleveland Clinic, Cleveland, OH 44195.
Weiling XuLerner Research Institute and the Respiratory Institute, Cleveland Clinic, Cleveland, OH 44195.
William W BusseDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706.
William J CalhounDepartment of Medicine, University of Texas Medical Branch, TX 77555.
Victor OrtegaInternal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27587.
Gregory A HawkinsInternal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27587.
Mario CastroDepartment of Medicine, University of Kansas School of Medicine, Kansas City, KS 66160.
Kian Fan ChungThe National Heart & Lung Institute, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0000-0001-7101-1426
John V FahyDepartment of Pediatrics, San Francisco School of Medicine, University of California, San Francisco, CA 94143.
Anne M FitzpatrickDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322.
Elliot IsraelDepartment of Medicine, Harvard Medical School, Boston, MA 02115.
Nizar N JarjourDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706.
Bruce LevyDepartment of Medicine, Harvard Medical School, Boston, MA 02115.
David T MaugerCenter for Biostatistics and Epidemiology, Pennsylvania State University School of Medicine, Hershey, PA 16802.
Wendy C MooreInternal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27587.
Patricia NoelSevere Asthma Research Program (SARP), National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892.
Stephen P PetersInternal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27587.
W Gerald TeagueDepartment of Pediatrics, University of Virginia, Charlottesville, VA 22904.
Sally E WenzelUniversity of Pittsburgh Asthma Institute, University of Pittsburgh Medical Center-University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.
Serpil C ErzurumLerner Research Institute and the Respiratory Institute, Cleveland Clinic, Cleveland, OH 44195.
Nima SharifiLerner Research Institute and the Respiratory Institute, Cleveland Clinic, Cleveland, OH 44195; sharifn@ccf.org.ORCID 0000-0003-1281-3474
Cleveland Clinic Lerner College of Medicine · USWake Forest University · USHarvard University · USRainbow Babies & Children's Hospital · USUniversity of Arizona · USUniversity of Virginia · USUniversity of Wisconsin–Madison · USCase Western Reserve University · USEmory University · USImperial College London · GBIndiana University School of MedicineNational Heart Lung and Blood Institute · USPennsylvania State University · USThe University of Texas Medical Branch at Galveston · USUniversity of California, San Francisco · USUniversity of Kansas · USUniversity of Pittsburgh Medical Center · US
Funding
Targeting pathological hyaluronan matricesP01HL103453 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ERZURUM, SERPIL C. · 2011 to 2020
$26.8MRole of miRNAs in Th2-Driven inflammation in AsthmaP01HL107202 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FAHY, JOHN V · 2012 to 2023
$23.3MTissue Processing and Cell Culture COreP01HL081064 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ERZURUM, SERPIL C. · 2006 to 2019
$17.8MProject 3 - Personalized cystic fibrosis treatment strategies with synergistic therapies Identified in vitro.P01HL128192 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI GASTON, BENJAMIN · 2016 to 2020
$12.2MS-nitrosothiol signaling in pulmonary epithelial cellsP01HL101871 · NHLBI · UNIVERSITY OF VIRGINIA · PI GASTON, BENJAMIN, LEWIS, STEPHEN JOHN · 2011 to 2015
$8.7MElucidating a novel molecular biomarker for castration-resistant prostate cancerR01CA172382 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Nima Sharifi · 2012 to 2026
$5.2MRedox Determinants of Severe AsthmaR01HL069170 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI ERZURUM, SERPIL C. · 2001 to 2010
$5.1MAirway redox biochemistry as a deteriminant of asthma phenotype during adolescen*U10HL109250 · NHLBI · UNIVERSITY OF VIRGINIA · PI ERZURUM, SERPIL C., GASTON, BENJAMIN · 2011 to 2016
$4.2MCompensatory steroidogenesis mechanisms in castration-resistant prostate cancerR01CA190289 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI SHARIFI, NIMA · 2015 to 2019
$2.1MAberrant tumor metabolism that enables AR antagonist-resistant prostate cancerR01CA236780 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SHARIFI, NIMA · 2020 to 2024
$1.8MGender-based precision care for asthmaK08HL133381 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ZEIN, JOE · 2017 to 2021
$836kNCI NIH HHS R01 CA172382NCI NIH HHS R01 CA190289NCI NIH HHS R01 CA236780NHLBI NIH HHS K08 HL133381NHLBI NIH HHS P01 HL081064NHLBI NIH HHS P01 HL101871NHLBI NIH HHS P01 HL103453NHLBI NIH HHS P01 HL107202NHLBI NIH HHS P01 HL128192NHLBI NIH HHS R01 HL069170NHLBI NIH HHS U10 HL109250
Abstract
Asthma resistance to glucocorticoid treatment is a major health problem with unclear etiology. Glucocorticoids inhibit adrenal androgen production. However, androgens have potential benefits in asthma.
Indexed as
AdultAgedAllelesAndrogensAsthmaCohort StudiesDrug ResistanceFemaleGenotypeGlucocorticoidsHumansMaleMiddle AgedMultienzyme ComplexesProgesterone ReductaseSteroid Isomerases3 beta-hydroxysteroid oxidoreductase-delta(5) 3-ketosteroid isomeraseAndrogensGlucocorticoidsMultienzyme ComplexesProgesterone ReductaseSteroid IsomerasesandrogensglucocorticoidsHSD3B1inflammationsteroids
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
NCT05623059ClinicalTrials.gov
NCT07179952ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.