Evidence map›Paper›PMID 31932383›Full record

ArticleAntimicrobial agents and chemotherapy2020

Tryptophan Trimers and Tetramers Inhibit Dengue and Zika Virus Replication by Interfering with Viral Attachment Processes.

Antonios Fikatas, Peter Vervaeke, Belén Martínez-Gualda, Olaia Martí-Marí, Sam Noppen, Eef Meyen, María-José Camarasa, Ana San-Félix, Christophe Pannecouque, Dominique Schols

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Antonios FikatasKU Leuven-University of Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Peter VervaekeKU Leuven-University of Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Belén Martínez-GualdaInstituto de Química Médica (IQM-CSIC), Madrid, Spain.
Olaia Martí-MaríInstituto de Química Médica (IQM-CSIC), Madrid, Spain.
Sam NoppenKU Leuven-University of Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Eef MeyenKU Leuven-University of Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
María-José CamarasaInstituto de Química Médica (IQM-CSIC), Madrid, Spain.
Ana San-FélixInstituto de Química Médica (IQM-CSIC), Madrid, Spain.
Christophe PannecouqueKU Leuven-University of Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Dominique ScholsKU Leuven-University of Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium dominique.schols@kuleuven.be.
Instituto de Química Médica · ESRega Institute for Medical Research · BEKU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here, we report a class of tryptophan trimers and tetramers that inhibit (at low micromolar range) dengue and Zika virus infection

Indexed as

AnimalsAntiviral AgentsChlorocebus aethiopsDengue VirusHumansHuman Umbilical Vein Endothelial CellsSerogroupStructure-Activity RelationshipTryptophanVero CellsViral Envelope ProteinsVirus ReplicationZika VirusAntiviral AgentsTryptophanViral Envelope Proteinsantiviralsdengueenvelope proteinSPRvirus attachmentZika

Identifiers

PMID31932383
PMCPMC7038274
OpenAlexW2998798808

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.