Evidence map›Paper›PMID 31932377›Full record

ArticleAntimicrobial agents and chemotherapy2020

Distinct Subpopulations of Intravalvular Methicillin-Resistant Staphylococcus aureus with Variable Susceptibility to Daptomycin in Tricuspid Valve Endocarditis.

Christopher R Miller, Somrita Dey, Paula D Smolenski, Pushkar S Kulkarni, Jonathan M Monk, Richard Szubin, George Sakoulas, Andrew D Berti

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. The Pathogenicity Mechanisms ofInternational journal of molecular sciences · 2025
    Review
  3. Article
  4. Daptomycin Pharmacokinetics and Pharmacodynamics in Patients on Methadone Substitution Therapy.European journal of drug metabolism and pharmacokinetics · 2021
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Christopher R MillerDepartment of Pharmacy Practice, Wayne State University College of Pharmacy and Health Sciences, Detroit, Michigan, USA.
Somrita DeyDepartment of Pharmacy Practice, Wayne State University College of Pharmacy and Health Sciences, Detroit, Michigan, USA.
Paula D SmolenskiDepartment of Pharmacy Practice, Wayne State University College of Pharmacy and Health Sciences, Detroit, Michigan, USA.
Pushkar S KulkarniDepartment of Pharmacy Practice, Wayne State University College of Pharmacy and Health Sciences, Detroit, Michigan, USA.
Jonathan M MonkDepartment of Bioengineering, University of California at San Diego, La Jolla, California, USA.
Richard SzubinDepartment of Bioengineering, University of California at San Diego, La Jolla, California, USA.
George SakoulasDivision of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California at San Diego School of Medicine, La Jolla, California, USA.
Andrew D BertiDepartment of Pharmacy Practice, Wayne State University College of Pharmacy and Health Sciences, Detroit, Michigan, USA andrew.berti@wayne.edu.
Wayne State University · USUniversity of California, San Diego · US

Funding

Systems Biology Approach to Redefine Susceptibility Testing and Treatment of MDR Pathogens in the Context of Host ImmunityU01AI124316 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PALSSON, BERNHARD O · 2016 to 2020
$10.2M
NIAID NIH HHS U01 AI124316
6 · The paper itself

Abstract

We present a case of endocarditis wherein organisms cultured from different valve leaflets yielded different daptomycin susceptibilities from each other and from organisms obtained from peripheral blood culture. Genomic analyses showed mutations in

Indexed as

AminoacyltransferasesBacterial ProteinsDaptomycinEndocarditis, BacterialHumansMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMutationRepressor ProteinsTricuspid ValveWhole Genome SequencingAminoacyltransferasesBacterial ProteinsDaptomycinmprF protein, Staphylococcus aureusPurR protein, BacteriaRepressor Proteinsagrcombination therapydaptomycinendocarditisfitnessMRSA

Identifiers

PMID31932377
PMCPMC7038235
OpenAlexW3000467533

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.