Evidence map›Paper›PMID 31932374›Full record

ArticleAntimicrobial agents and chemotherapy2020

Antimalarial Drug Resistance Profiling of Plasmodium falciparum Infections in Ghana Using Molecular Inversion Probes and Next-Generation Sequencing.

Benedicta A Mensah, Ozkan Aydemir, James L Myers-Hansen, Millicent Opoku, Nicholas J Hathaway, Patrick W Marsh, Francis Anto, Jeffrey Bailey, Benjamin Abuaku, Anita Ghansah

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 39 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Polymorphism ofJournal of parasitology research · 2026
    Article
  5. Article
  6. Article
  7. Prevalence of molecular markers associated withThe Pan African medical journal · 2025
    Article
  8. Article
  9. Review
  10. Review
  11. Putative molecular markers ofFrontiers in epidemiology · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Global Analysis ofMolecules (Basel, Switzerland) · 2022
    Article
  16. Frontiers in cellular and infection microbiology · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Benedicta A MensahNoguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana.
Ozkan AydemirProgram in Bioinformatics and Integrative Biology, University of Massachusetts, Worcester, Massachusetts, USA.
James L Myers-HansenNoguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana.
Millicent OpokuNoguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana.
Nicholas J HathawayProgram in Bioinformatics and Integrative Biology, University of Massachusetts, Worcester, Massachusetts, USA.
Patrick W MarshProgram in Bioinformatics and Integrative Biology, University of Massachusetts, Worcester, Massachusetts, USA.
Francis AntoSchool of Public Health, University of Ghana, Accra, Ghana.
Jeffrey BaileyProgram in Bioinformatics and Integrative Biology, University of Massachusetts, Worcester, Massachusetts, USA.
Benjamin AbuakuNoguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana.
Anita GhansahNoguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana aghansah@noguchi.ug.edu.gh.
University of Ghana · GHUniversity of Massachusetts Chan Medical School · USNoguchi Memorial Institute for Medical Research · GH

Funding

Impact of Distinct Eco-epidemiology on Malaria Drug Resistance in GhanaR01AI099527 · NIAID · NOGUCHI MEMORIAL INSTITUTE / MEDICAL RES · PI GHANSAH, ANITA · 2013 to 2017
$639k
NIAID NIH HHS R01 AI099527
6 · The paper itself

Abstract

A key drawback to monitoring the emergence and spread of antimalarial drug resistance in sub-Saharan Africa is early detection and containment. Next-generation sequencing methods offer the resolution, sensitivity, and scale required to fill this gap by surveilling for molecular markers of drug resistance. We performed targeted sequencing using molecular inversion probes to interrogate five

Indexed as

AdolescentAntimalarialsArtemisininsATP-Binding Cassette, Sub-Family C ProteinsChildChild, PreschoolChloroquineDrug CombinationsDrug ResistanceGhanaHigh-Throughput Nucleotide SequencingHumansInfantMalaria, FalciparumParasitic Sensitivity TestsPlasmodium falciparumAntimalarialsartemisininArtemisininsATP-Binding Cassette, Sub-Family C ProteinsChloroquineDrug Combinationsfanasil, pyrimethamine drug combinationMdr1 protein, Plasmodium falciparumPyrimethamineSulfadoxineantimalarialdeep sequencingdrug resistanceGhanamalariaMIPPlasmodium falciparum

Identifiers

PMID31932374
PMCPMC7179265
OpenAlexW2999491246

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.