Trial reportArchives of disease in childhood. Fetal and neonatal edition2020
Propofol for endotracheal intubation in neonates: a dose-finding trial.
Trial report in Archives of disease in childhood. Fetal and neonatal edition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Remifentanil and Neonatal Intubation: Balancing Efficacy and Safety.Children (Basel, Switzerland) · 2026Review
- [RSI in pediatric anesthesia: an online survey of actual clinical practice].Die Anaesthesiologie · 2026Article
- Patient and public involvement (PPI) reporting in maternal and neonatal clinical trials: an exploratory review.Trials · 2026Review
- Anesthesia Practices for Preterm Infants: A Survey in the Nordic Countries and Review of the Literature.Acta anaesthesiologica Scandinavica · 2026Review
- Pharmacological therapy of neonatal analgosedation: current status, dilemmas, and perspectives.Frontiers in pediatrics · 2026Review
- Continuous improvement of non-emergent neonatal intubations in a level IV NICU.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Sedation and anesthesia for imaging of the infant and neonate-a brief review.Pediatric radiology · 2024Review
- Antibiotics, Analgesic Sedatives, and Antiseizure Medications Frequently Used in Critically Ill Neonates: A Narrative Review.Children (Basel, Switzerland) · 2024Review
- Analgesia and sedation in critically ill pediatric patients: an update from the recent guidelines and point of view.European journal of pediatrics · 2023Review
- Standardizing premedication for non-emergent neonatal tracheal intubations improves compliance and patient outcomes.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Premedication before laryngoscopy in neonates: Evidence-based statement from the French society of neonatology (SFN).Frontiers in pediatrics · 2022Review
- Propofol in neonates causes a dose-dependent profound and protracted decrease in blood pressure.Acta paediatrica (Oslo, Norway : 1992) · 2020Article
- Procedural pain management in neonates: A Narrative review.International journal of critical illness and injury scienceReview
- Analgesia and sedation for intratracheal intubation in the neonatal period: an integrative literature review.Jornal de pediatriaReview
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo find propofol doses providing effective sedation without side effects in neonates of different gestational ages (GA) and postnatal ages (PNA). DESIGN AND
settingProspective multicentere dose-finding study in 3 neonatal intensive care units. PATIENTS: Neonates with a PNA <28 days requiring non-emergency endotracheal intubation.
interventionsNeonates were stratified into 8 groups based on GA and PNA. The first 5 neonates in every group received a dose of 1.0 mg/kg propofol. Based on sedative effect and side effects, the dose was increased or decreased in the next 5 patients until the optimal dose was found.
main outcome measuresThe primary outcome was the optimal single propofol starting dose that provides effective sedation without side effects in each age group.
resultsAfter inclusion of 91 patients, the study was prematurely terminated because the primary outcome was only reached in 13% of patients. Dose-finding was completed in 2 groups, but no optimal propofol dose was found. Effective sedation without side effects was achieved more often after a starting dose of 2.0 mg/kg (28%) than after 1.0 mg/kg (3%) and 1.5 mg/kg (9%). Propofol-induced hypotension occurred in 59% of patients. Logistic regression analyses showed that GA and PNA did not predict effective sedation or the occurrence of hypotension.
conclusionsEffective sedation without side effects is difficult to achieve with propofol and the optimal dose in different age groups of neonates could not be determined. The sedative effect of propofol and the occurrence of hypotension are unpredictable and show large inter-individual variability in the neonatal population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.