ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2020
Incidental lymphopenia and mortality: a prospective cohort study.
Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Inflammatory biomarkers in older adults with frailty: a systematic review and meta-analysis of cross-sectional studies.Aging clinical and experimental research · 2022Pooled it
- Prognostic Value of Pretreated Blood Inflammatory Markers in Patients with Bone Sarcoma: A Meta-Analysis.Disease markers · 2021Pooled it
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- Specific Deficiency of Naïve CD4+ T Lymphocytes Characterizes Heart Failure and Heightens Mortality Risk in the HRS.Journal of the American Heart Association · 2026Article
- C282Y Homozygosity Increases Erythrocyte Turnover and Decreases HbA1c-A Population-Based Study.International journal of molecular sciences · 2026Article
- Construction of an explainable machine learning model based on SHAP for predicting cardiovascular mortality risk among American cancer survivors.Discover oncology · 2026Article
- Article
- Association of Prognostic Nutritional Index With Mortality in High-Risk OSA Individuals and with Disease Severity in Clinical OSA Patients.Nature and science of sleep · 2026Article
- C-Reactive Protein-Albumin-Lymphocyte Index as a Predictor of All-Cause and Cardiovascular Mortality in Individuals With Diabetes or Prediabetes: A National Population-Based Cohort Study.International journal of endocrinology · 2026Article
- Article
- The Neutrophil-to-Lymphocyte Ratio as a Prognostic Biomarker of Fournier's Gangrene Severity: A Meta-Analysis.Infectious disease reports · 2025Review
- Systemic Inflammatory Response Index Is a More Promising Prognostic Index Than Systemic Immune Inflammation Index in Critically Ill Heart Failure Patients: A Retrospective Cohort Analysis of the MIMIC-IV Database.Vascular health and risk management · 2025Article
- Association of the derived neutrophil-to-lymphocyte ratio with cardiovascular and all-cause mortality.PloS one · 2025Article
- Systemic immune-inflammatory complex index as a novel predictor of sepsis prognosis: a retrospective cohort study using MIMIC-IV.Frontiers in medicine · 2025Article
- Association between prognostic nutritional index and all-cause mortality and cardiovascular disease mortality in American adults with non-alcoholic fatty liver disease.Frontiers in nutrition · 2025Article
- Neutrophil-to-lymphocyte ratio as a prognostic indicator of mortality in Polycythemia Vera: insights from a prospective cohort analysis.Blood cancer journal · 2024Article
- Thrombosis in myeloproliferative neoplasms: a viewpoint on its impact on myelofibrosis, mortality, and solid tumors.Blood cancer journal · 2024Review
- Increased mortality in infants with abnormal T-cell receptor excision circles.Pediatric research · 2024Article
- Prevalence of lymphopenia in the American population: Insights from demographic, BMI, and lifestyle factors.PloS one · 2024Article
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is unknown if incidental lymphopenia detected in the general population is associated with higher all-cause and cause-specific mortality. We aimed to identify the associations between lymphopenia and all-cause and cause specific mortality.
methodsIn a prospective cohort study, we examined and followed participants enrolled in the Copenhagen General Population Study between November 2003 and April 2015. In our analysis, we modelled risks using Cox proportional hazards regression for 3 groups: participants with a lymphocyte count below the 2.5th percentile; those with a lymphocyte count at or between the 2.5th and 97.5th percentiles (reference category); and those with a lymphocyte count above the 97.5th percentile.
resultsThe cohort included 108 135 participants with a median age of 68 years. During a median follow-up of 9 (interquartile range [IQR] 0-14) years, 10 372 participants died. We found that participants with lymphopenia (lymphocyte count < 1.1 × 10
interpretationWe found that lymphopenia was associated with an increased risk of all-cause and cause-specific mortality.
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Registered trials
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