Evidence map›Paper›PMID 31932327›Full record

ArticleInfection and immunity2020

Glycine Lipids of Porphyromonas gingivalis Are Agonists for Toll-Like Receptor 2.

Frank C Nichols, Robert B Clark, Yaling Liu, Anthony A Provatas, Christopher J Dietz, Qiang Zhu, Yu-Hsiung Wang, Michael B Smith

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Infection and immunity · 2026
    Article
  3. Metabolic Reprogramming of Macrophages Plays a Dual Role in Periodontitis: From Pathogenesis to Therapy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  4. Article
  5. Article
  6. Microbiology spectrum · 2025
    Article
  7. Inhibition of SARS-CoV-2 infection byMicrobiology spectrum · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Lipidome of theBiochemistry · 2023
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. TLR2 Activation byFrontiers in immunology · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Frank C NicholsUniversity of Connecticut School of Dental Medicine, UCONN Health, Farmington, Connecticut, USA nichols@uchc.edu.
Robert B ClarkUniversity of Connecticut School of Medicine, UCONN Health, Farmington, Connecticut, USA.
Yaling LiuUniversity of Connecticut School of Dental Medicine, UCONN Health, Farmington, Connecticut, USA.
Anthony A ProvatasCenter for Environmental Sciences and Engineering, Storrs, Connecticut, USA.
Christopher J DietzDepartment of Chemistry, University of Connecticut, Storrs, Connecticut, USA.
Qiang ZhuUniversity of Connecticut School of Dental Medicine, UCONN Health, Farmington, Connecticut, USA.
Yu-Hsiung WangUniversity of Connecticut School of Dental Medicine, UCONN Health, Farmington, Connecticut, USA.
Michael B SmithDepartment of Chemistry, University of Connecticut, Storrs, Connecticut, USA.
UConn Health · USUniversity of Connecticut · US

Funding

Porphyromonas gingivalis glycine lipids mediate bone loss through TLR2R01DE027642 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI NICHOLS, FRANK C · 2019 to 2022
$1.6M
NIDCR NIH HHS R01 DE027642
6 · The paper itself

Abstract

The serine-glycine dipeptide lipid classes, including lipid 430 and lipid 654, are produced by the periodontal pathogen

Indexed as

AnimalsCells, CulturedChromatography, High Pressure LiquidChromatography, LiquidHumansImmunologic FactorsLipopeptidesMacrophagesMicePorphyromonas gingivalisTandem Mass SpectrometryToll-Like Receptor 2Tumor Necrosis Factor-alphaImmunologic FactorsLipopeptidesTLR2 protein, humanTlr2 protein, mouseToll-Like Receptor 2Tumor Necrosis Factor-alphaglycine lipidsHEK cellsmacrophagePorphyromonas gingivalisToll-like receptor 2

Identifiers

PMID31932327
PMCPMC7093120
OpenAlexW2999442977

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.