Evidence map›Paper›PMID 31932322›Full record

ArticleRNA (New York, N.Y.)2020

Substrate analogs that trap the 2'-phospho-ADP-ribosylated RNA intermediate of the Tpt1 (tRNA 2'-phosphotransferase) reaction pathway.

Swathi Dantuluri, Leonora Abdullahu, Annum Munir, Adam Katolik, Masad J Damha, Stewart Shuman

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Swathi DantuluriMolecular Biology Program, Sloan-Kettering Institute, New York, New York 10065, USA.
Leonora AbdullahuDepartment of Chemistry, McGill University, Montreal, Quebec H3A0B8, Canada.
Annum MunirMolecular Biology Program, Sloan-Kettering Institute, New York, New York 10065, USA.
Adam KatolikDepartment of Chemistry, McGill University, Montreal, Quebec H3A0B8, Canada.
Masad J DamhaDepartment of Chemistry, McGill University, Montreal, Quebec H3A0B8, Canada.
Stewart ShumanMolecular Biology Program, Sloan-Kettering Institute, New York, New York 10065, USA.
Kettering University · USMcGill University · CA

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Mechanisms of DNA and RNA TransactionsR35GM126945 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI Stewart H Shuman · 2018 to 2026
$8.9M
NCI NIH HHS P30 CA008748NIGMS NIH HHS R35 GM126945
6 · The paper itself

Abstract

The enzyme Tpt1 removes an internal RNA 2'-PO

Indexed as

Acetivibrio thermocellusADP-RibosylationArabinoseBacterial ProteinsChaetomiumCytophagaceaeFungal ProteinsNADPhosphotransferases (Alcohol Group Acceptor)RNAArabinoseBacterial ProteinsFungal ProteinsNADPhosphotransferases (Alcohol Group Acceptor)RNAADP-ribosylationnicotinamide adenine dinucleotideRNA 2′-phosphotransferasetransesterification

Identifiers

PMID31932322
PMCPMC7075268
OpenAlexW2999459632

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.