Evidence map›Paper›PMID 31932313›Full record

ArticleJournal of bacteriology2020

Roles of TroA and TroR in Metalloregulated Growth and Gene Expression in

Prakaimuk Saraithong, M Paula Goetting-Minesky, Peter M Durbin, Spencer W Olson, Frank C Gherardini, J Christopher Fenno

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Transcription regulator TrtA modulates oxygen stress response inApplied and environmental microbiology · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Approaches to Understanding Mechanisms of Dentilisin Protease Complex Expression inFrontiers in cellular and infection microbiology · 2021
    Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Prakaimuk Saraithong *Department of Biologic and Materials Sciences and Prosthodontics, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA.
M Paula Goetting-Minesky *Department of Biologic and Materials Sciences and Prosthodontics, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA.
Peter M DurbinDepartment of Biologic and Materials Sciences and Prosthodontics, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA.
Spencer W OlsonDepartment of Biologic and Materials Sciences and Prosthodontics, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA.
Frank C GherardiniLaboratory of Bacteriology, Gene Regulation Section, Division of Intramural Research, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
J Christopher FennoDepartment of Biologic and Materials Sciences and Prosthodontics, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA fenno@umich.edu.
University of Michigan–Ann Arbor · USNational Institute of Allergy and Infectious Diseases · US

Funding

The Roles of Key Transcription Factors on the Pathogenesis of B. Burgdorferi, the Causative Agent of Lyme DiseaseZIAAI000905 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GHERARDINI, FRANK · 2009 to 2023
$12.4M
Treponema - Host Cell and Tissue InteractionsR01DE025225 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI J CHRISTOPHER FENNO, Yvonne L Kapila · 2015 to 2026
$6.3M
NIDCR NIH HHS R01 DE025225
6 · The paper itself

Abstract

The availability of divalent metal cations required as cofactors for microbial metabolism is severely limited in the host environment. Bacteria have evolved highly regulated uptake systems to maintain essential metal homeostasis to meet cellular demands while preventing toxicity. The Tro operon (

Indexed as

Gene Expression Regulation, BacterialATP-Binding Cassette TransportersBacterial ProteinsCationsGenetic Complementation TestMutagenesisOperonTranscription, GeneticTreponema denticolaATP-Binding Cassette TransportersBacterial ProteinsCationsmetalloregulationspirochetestranscription

Identifiers

PMID31932313
PMCPMC7167467
OpenAlexW2998925524

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.