Evidence map›Paper›PMID 31932071›Full record

ArticleKidney international2020

Avian erythroblastosis virus E26 oncogene homolog-1 (ETS-1) plays a role in renal microvascular pathophysiology in the Dahl salt-sensitive rat.

Wenguang Feng, Zhengrong Guan, Dongqi Xing, Xingsheng Li, Wei-Zhong Ying, Colton E Remedies, Edward W Inscho, Paul W Sanders

Open access · greenAbstract read
In one paragraph

Article in Kidney international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  8. UAB-UCSD O'Brien Center for Acute Kidney Injury Research.American journal of physiology. Renal physiology · 2021
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Wenguang FengDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA. Electronic address: wenguangfeng@uabmc.edu.
Zhengrong GuanDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Dongqi XingDivision of Pulmonary, Allergy & Critical Care, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Xingsheng LiDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Wei-Zhong YingDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Colton E RemediesDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Edward W InschoDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Paul W SandersDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA; Department of Veterans Affairs Medical Center, Birmingham, Alabama, USA.
University of Alabama at Birmingham · US

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
UAB-UCSD O'Brien Core Center for Acute Kidney Injury ResearchP30DK079337 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGARWAL, ANUPAM · 2008 to 2022
$18.3M
TLR4 in the Regulation of Renal Microvascular FunctionR01DK044628 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI INSCHO, EDWARD W · 2000 to 2021
$6.2M
Salt-Sensitive Hypertension/Hypertensive NephrosclerosisR01DK046199 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SANDERS, PAUL W. · 1992 to 2011
$2.9M
The Inflammatory Cytokines, MCP-1 and TGF-Beta, Mediate Renal Autoregulatory ImpaR01HL098135 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI INSCHO, EDWARD W · 2010 to 2014
$1.8M
Sphingosine-1-phosphate in renal microvascular dysfunction of ischemia-reperfusion kidney injuryR01DK106500 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUAN, ZHENGRONG · 2017 to 2020
$1.4M
Targeted Cell Therapy for Acute Lung InjuryR56HL128285 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI XING, DONGQI · 2016 to 2016
$368k
Conference on Control of Renal Function in Health and DiseaseR13DK121400 · NIDDK · AMERICAN PHYSIOLOGICAL SOCIETY · PI INSCHO, EDWARD W, ORTIZ, PABLO A. · 2019 to 2019
$10k
Novel Regulators of Vascular DiseaseIP1BX001595 · VA · BIRMINGHAM VA MEDICAL CENTER · PI AGARWAL, ANUPAM, CHEN, YABING · 2013 to 2016
–
Low Molecular Weight Protein NephrotoxicityI01CX001326 · VA · BIRMINGHAM VA MEDICAL CENTER · PI SANDERS, PAUL W. · 2015 to 2024
–
Low Molecular Weight Protein NephrotoxicityI01BX001192 · VA · BIRMINGHAM VA MEDICAL CENTER · PI SANDERS, PAUL W. · 2011 to 2014
–
BLRD VA I01 BX001192BLRD VA I01 BX004426BLRD VA I01 BX005640BLRD VA IP1 BX001595CSRD VA I01 CX001326NHLBI NIH HHS R01 HL098135NHLBI NIH HHS R56 HL128285NIDDK NIH HHS P30 DK079337NIDDK NIH HHS P30 DK079626NIDDK NIH HHS R01 DK044628NIDDK NIH HHS R01 DK046199NIDDK NIH HHS R01 DK106500NIDDK NIH HHS R13 DK121400
6 · The paper itself

Abstract

Prior studies reported that haploinsufficiency of the transcription factor ETS-1 is renoprotective in Dahl salt-sensitive rats, but the mechanism is unclear. Here, we tested whether ETS-1 is involved in hypertension-induced renal microvascular pathology and autoregulatory impairment. Hypertension was induced in salt-sensitive rats and salt-sensitive rats that are heterozygous with 1 wild-type or reference allele of Ets1 (SS

Indexed as

AlpharetrovirusHypertensionAnimalsBlood PressureKidneyOncogenesProto-Oncogene Protein c-ets-1RatsRats, Inbred DahlEts1 protein, ratProto-Oncogene Protein c-ets-1chronic kidney diseasefibrosisinflammationsalt

Identifiers

PMID31932071
PMCPMC7039742
OpenAlexW2981761495

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.