ArticleNeurobiology of aging2020
Excess brain age in the sleep electroencephalogram predicts reduced life expectancy.
Article in Neurobiology of aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05455814 (Brain Health With Inner Engineering- Longitudinal Study of Shambhavi Mahamudra Kriya Meditation), which is not on this map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Brain Health With Inner Engineering- Longitudinal Study of Shambhavi Mahamudra Kriya Meditation (BLISS)
Who cites it
36 citing papers in PubMed, 50 citations in OpenAlex.
- Accelerated Brain Aging in Adults With Major Depressive Disorder Predicts Poorer Outcome With Sertraline: Findings From the EMBARC Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Trial
- Brain Health from Sleep EEG: A Multicohort, Deep Learning Biomarker for Cognition, Disease, and Mortality.NEJM AI · 2026Article
- Sleep electroencephalography-derived brain health and long-term cognitive decline in community-dwelling adults.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Isolated REM Sleep Behaviour Disorder-Is Screening Possible?Journal of sleep research · 2025Review
- [Research progress in electroencephalogram-based brain age prediction].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Review
- Mind the Gap: Does Brain Age Improve Alzheimer's Disease Prediction?Human brain mapping · 2025Article
- Toward a Universal Map of EEG: A Semantic, Low-Dimensional Manifold for EEG Classification, Clustering, and Prognostication.Annals of neurology · 2025Article
- Artificial Intelligence Can Drive Sleep Medicine.Sleep medicine clinics · 2025Review
- Article
- A Multimodal Sleep Foundation Model Developed with 500K Hours of Sleep Recordings for Disease Predictions.medRxiv : the preprint server for health sciences · 2025Article
- Article
- Long-term night-shift work is associated with accelerates brain aging and worsens N3 sleep in female nurses.Sleep medicine · 2024Article
- Predicting the impact of CPAP on brain health: A study using the sleep EEG-derived brain age index.Annals of clinical and translational neurology · 2024Article
- Article
- Article
- Predicting brain age across the adult lifespan with spontaneous oscillations and functional coupling in resting brain networks captured with magnetoencephalography.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Epilepsy Surgery for Cognitive Improvement in Epileptic Encephalopathy.Neurosurgery clinics of North America · 2024Review
- The Neurostimulationist will see you now: prescribing direct electrical stimulation therapies for the human brain in epilepsy and beyond.Frontiers in human neuroscience · 2024Review
- Brain age revisited: Investigating the state vs. trait hypotheses of EEG-derived brain-age dynamics with deep learning.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Epilepsy is associated with the accelerated aging of brain activity in sleep.Frontiers in physiology · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The brain age index (BAI) measures the difference between an individual's apparent "brain age" (BA; estimated by comparing EEG features during sleep from an individual with age norms), and their chronological age (CA); that is BAI = BA-CA. Here, we evaluate whether BAI predicts life expectancy. Brain age was quantified using a previously published machine learning algorithm for a cohort of participants ≥40 years old who underwent an overnight sleep electroencephalogram (EEG) as part of the Sleep Heart Health Study (n = 4877). Excess brain age (BAI >0) was associated with reduced life expectancy (adjusted hazard ratio: 1.12, [1.03, 1.21], p = 0.002). Life expectancy decreased by -0.81 [-1.44, -0.24] years per standard-deviation increase in BAI. Our findings show that BAI, a sleep EEG-based biomarker of the deviation of sleep microstructure from patterns normal for age, is an independent predictor of life expectancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.