ArticleCritical care (London, England)2020
New-onset atrial fibrillation and associated outcomes and resource use among critically ill adults-a multicenter retrospective cohort study.
Article in Critical care (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- A systematic review on the influence of coagulopathy and immune activation on New Onset Atrial Fibrillation in patients with sepsis.PloS one · 2025Pooled it
- Magnesium prophylaxis of new-onset atrial fibrillation: A systematic review and meta-analysis.PloS one · 2023Pooled it
- The association between blood urea nitrogen to serum albumin ratio and all-cause mortality in critically ill patients with atrial fibrillation.European journal of medical research · 2026Article
- The geriatric nutritional risk index as a prognostic risk factor for critically ill patients with atrial fibrillation: a retrospective study based on MIMIC-IV and local hospital cohort external validation.Frontiers in nutrition · 2026Article
- Development and validation of a machine learning-based predictive model for new-onset atrial fibrillation after CABG.Frontiers in cardiovascular medicine · 2026Article
- Comparison of rhythm and rate control medications for new-onset atrial fibrillation in septic patients: MIMIC-IV database analysis.Journal of translational medicine · 2025Article
- New-Onset, But Not Chronic Atrial Fibrillation, Is a Significant Factor Contributing to Mortality Among Patients with Severe COVID-19.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Beyond the Beat: A Multifaceted Review of Atrial Fibrillation in Sepsis: Risk Factors, Management Strategies, and Economic Impact.Cardiology research · 2025Review
- Prevalence, Risk Factors, and Mortality of New-Onset Atrial Fibrillation in Mechanically Ventilated Critically Ill Patients.Journal of clinical medicine · 2024Article
- Research priorities for the study of atrial fibrillation during acute and critical illness: recommendations from the Symposium on Atrial Fibrillation in Acute and Critical Care.BMC proceedings · 2024Article
- Joint effect of atrial fibrillation and obesity on mortality in critically ill patients.Diabetology & metabolic syndrome · 2024Article
- An International Survey of the Management of Atrial Fibrillation in Critically Unwell Patients.Critical care explorations · 2024Article
- Impact of New-Onset Atrial Fibrillation on Mortality in Critically Ill Patients.Clinical epidemiology · 2024Article
- Sepsis-Induced Coagulopathy Score is Associated with an Increased Risk of New-Onset Atrial Fibrillation in Septic Patients: A Two-Centered Retrospective Study.Journal of inflammation research · 2024Article
- Sepsis, Atrial Fibrillation, and Aging: A Dangerous Association.Arquivos brasileiros de cardiologia · 2023Article
- Association of Dexmedetomidine With New-Onset Atrial Fibrillation in Patients With Critical Illness.JAMA network open · 2023Article
- Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology.Nature reviews. Cardiology · 2023Review
- Association of Mitral Regurgitation with Postoperative Atrial Fibrillation in Critically Ill Noncardiac Surgery Patients: A Prospective Cohort Study.International journal of general medicine · 2023Article
- Atrial Fibrillation and Sepsis in Elderly Patients and Their Associaton with In-Hospital Mortality.Arquivos brasileiros de cardiologia · 2023Review
- [Atrial fibrillation on the intensive care unit : The special prognostic importance of the first manifestation].Herzschrittmachertherapie & Elektrophysiologie · 2022Review
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Authors and funding
12 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNew-onset atrial fibrillation (NOAF) is commonly encountered in critically ill adults. Evidence evaluating the association between NOAF and patient-important outcomes in this population is conflicting. Furthermore, little is known regarding the association between NOAF and resource use or hospital costs.
methodsRetrospective analysis (2011-2016) of a prospectively collected registry from two Canadian hospitals of consecutive ICU patients aged ≥ 18 years. We excluded patients with a known history of AF prior to hospital admission. Any occurrence of atrial fibrillation (AF) was prospectively recorded by bedside nurses. The primary outcome was hospital mortality, and we used multivariable logistic regression to adjust for confounders. We used a generalized linear model to evaluate contributors to total cost.
resultsWe included 15,014 patients, and 1541 (10.3%) had NOAF during their ICU admission. While NOAF was not associated with increased odds of hospital death among the entire cohort (adjusted odds ratio [aOR] 1.02 [95% confidence interval [CI] 0.97-1.08]), an interaction was noted between NOAF and sepsis, and the presence of both was associated with higher odds of hospital mortality (aOR 1.28 [95% CI 1.09-1.36]) than either alone. Patients with NOAF had higher total costs (cost ratio [CR] 1.09 [95% CI 1.02-1.20]). Among patients with NOAF, treatment with a rhythm-control strategy was associated with higher costs (CR 1.24 [95% CI 1.07-1.40]).
conclusionsWhile NOAF was not associated with death or requiring discharge to long-term care among critically ill patients, it was associated with increased length of stay in ICU and increased total costs.
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