Observational studyBMC endocrine disorders2020
Clinical characterization of patients with primary aldosteronism plus subclinical Cushing's syndrome.
Observational study in BMC endocrine disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Exploring the high prevalence, comorbidities, and indicators of mild autonomous cortisol secretion in primary aldosteronism: a cohort study and systematic review.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Pooled it
- Impact of autonomous cortisol secretion on adrenal venous sampling with and without ACTH stimulation in patients with primary aldosteronism.Endocrine journal · 2026Article
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- Comparative analysis of cardiac dysfunction in non-functioning adrenal adenomas, primary aldosteronism, and essential hypertension.Journal of endocrinological investigation · 2025Article
- Autonomous cortisol secretion promotes vascular calcification in vivo and in vitro under hyperaldosteronism.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Bilateral adrenal adenomas with autonomous cortisol secretion from both glands and autonomous aldosterone secretion from the left adrenal: a case report.Journal of Yeungnam medical science · 2025Article
- The value of plasma metanephrine measurements during adrenal vein sampling.Endocrine connections · 2024Article
- The influence of cortisol co-secretion on clinical characteristics and postoperative outcomes in unilateral primary aldosteronism.Frontiers in endocrinology · 2024Article
- Cardiovascular and metabolic characters ofFrontiers in endocrinology · 2023Review
- The Entity of Connshing Syndrome: Primary Aldosteronism with Autonomous Cortisol Secretion.Diagnostics (Basel, Switzerland) · 2022Review
- Case Report: Primary Aldosteronism and Subclinical Cushing Syndrome in a 49-Year-Old Woman With Hypertension Plus Hypokalaemia.Frontiers in cardiovascular medicine · 2022Article
- Hypertension with unilateral adrenal aldosterone and cortisol cosecreting adenoma: A case report.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Nearly fatal hypokalaemia due to non-hypertensive primary hyperaldosteronism in the post partum.BMJ case reports · 2021Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrimary aldosteronism (PA) plus subclinical Cushing's syndrome (SCS), PASCS, has occasionally been reported. We aimed to clinically characterize patients with PASCS who are poorly profiled.
methodsA population-based, retrospective, single-center, observational study was conducted in 71 patients (age, 58.2 ± 11.2 years; 24 males and 47 females) who developed PA (n = 45), SCS (n = 12), or PASCS (n = 14). The main outcome measures were the proportion of patients with diabetes mellitus (DM), serum potassium concentration, and maximum tumor diameter (MTD) on the computed tomography (CT) scans.
resultsThe proportion of DM patients was significantly greater in the PASCS group than in the PA group (50.0% vs. 13.9%, p < 0.05), without a significant difference between the PASCS and SCS groups. Serum potassium concentration was significantly lower in the PASCS group than in the SCS group (3.2 ± 0.8 mEq/L vs. 4.0 ± 0.5 mEq/L; p < 0.01), without a significant difference between the PASCS and PA groups. Among the 3 study groups of patients who had a unilateral adrenal tumor, MTD was significantly greater in the PASCS group than in the PA group (2.7 ± 0.1 cm vs. 1.4 ± 0.1 cm; p < 0.001), without a significant difference between the PASCS and SCS groups.
conclusionsAny reference criteria were not obtained that surely distinguish patients with PASCS from those with PA or SCS. However, clinicians should suspect the presence of concurrent SCS in patients with PA when detecting a relatively large adrenal tumor on the CT scans.
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