ArticlePloS one2020
Genetic characterization of Bacillus anthracis strains circulating in Italy from 1972 to 2018.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 19 citations in OpenAlex.
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- Antimicrobial Resistance Profile, Whole-Genome Sequencing and Core Genome Multilocus Sequence Typing ofAntibiotics (Basel, Switzerland) · 2024Article
- Retrospective Analysis of Official Data on Anthrax in Europe with a Special Reference to Ukraine.Microorganisms · 2023Review
- Identification of Universally Applicable and Species-Specific Marker Peptides forLife (Basel, Switzerland) · 2022Article
- An Outbreak of Human Systemic Anthrax, including One Case of Anthrax Meningitis, Occurred in Calabria Region (Italy): A Description of a Successful One Health Approach.Life (Basel, Switzerland) · 2022Article
- Identification of the molecular characteristics ofVeterinary world · 2022Article
- The roles of antimicrobial resistance, phage diversity, isolation source and selection in shaping the genomic architecture ofMicrobial genomics · 2021Article
- A Whole-Genome-Based Gene-by-Gene Typing System for Standardized High-Resolution Strain Typing of Bacillus anthracis.Journal of clinical microbiology · 2021Article
- An Estimate of Global Anthrax Prevalence in Livestock: A Meta-analysis.Veterinary world · 2021Article
- Overview of Control Programs for Twenty-Four Infectious Cattle Diseases in ItalyFrontiers in veterinary science · 2021Article
- Genetic Diversity of AustralianMicroorganisms · 2020Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Italy anthrax is an endemic disease, with a few outbreaks occurring almost every year. We surveyed 234 B. anthracis strains from animals (n = 196), humans (n = 3) and the environment (n = 35) isolated during Italian outbreaks in the years 1972-2018. Despite the considerable genetic homogeneity of B. anthracis, the strains were effectively differentiated using canonical single nucleotide polymorphisms (CanSNPs) assay and multiple-locus variable-number tandem repeat analysis (MLVA). The phylogenetic identity was determined through the characterization of 14 CanSNPs. In addition, a subsequent 31-loci MLVA assay was also used to further discriminate B. anthracis genotypes into subgroups. The analysis of 14 CanSNPs allowed for the identification of four main lineages: A.Br.011/009, A.Br.008/011 (respectively belonging to A.Br.008/009 sublineage, also known Trans-Eurasian or TEA group), A.Br.005/006 and B.Br.CNEVA. A.Br.011/009, the most common subgroup of lineage A, is the major genotype of B. anthracis in Italy. The MLVA analysis revealed the presence of 55 different genotypes in Italy. Most of the genotypes are genetically very similar, supporting the hypothesis that all strains evolved from a local common ancestral strain, except for two genotypes representing the branch A.Br.005/006 and B.Br.CNEVA. The genotyping analysis applied in this study remains a very valuable tool for studying the diversity, evolution, and molecular epidemiology of B. anthracis.
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