Evidence map›Paper›PMID 31931402›Full record

ArticleNeuroImage. Clinical2020

Brain connectivity and cognitive functioning in individuals six months after multiorgan failure.

Antonio Jimenez-Marin, Diego Rivera, Victoria Boado, Ibai Diez, Fermin Labayen, Irati Garrido, Daniela Ramos-Usuga, Itziar Benito-Sánchez, Javier Rasero, Alberto Cabrera-Zubizarreta and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Antonio Jimenez-MarinBiocruces-Bizkaia Health Research Institute, Barakaldo, Spain; Biomedical Research Doctorate Program, University of the Basque Country (UPV/EHU), Leioa, Spain.
Diego RiveraBiocruces-Bizkaia Health Research Institute, Barakaldo, Spain.
Victoria BoadoIntensive Care Unit. Cruces University Hospital, Barakaldo, Spain.
Ibai DiezGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Neurotechnology Laboratory, Tecnalia Health Department, Derio, Spain.
Fermin LabayenIntensive Care Unit. Cruces University Hospital, Barakaldo, Spain.
Irati GarridoIntensive Care Unit. Cruces University Hospital, Barakaldo, Spain.
Daniela Ramos-UsugaBiomedical Research Doctorate Program, University of the Basque Country (UPV/EHU), Leioa, Spain.
Itziar Benito-SánchezBiocruces-Bizkaia Health Research Institute, Barakaldo, Spain; Biomedical Research Doctorate Program, University of the Basque Country (UPV/EHU), Leioa, Spain.
Javier RaseroBiocruces-Bizkaia Health Research Institute, Barakaldo, Spain.
Alberto Cabrera-ZubizarretaOsatek, Vitoria-Gasteiz, Spain.
Iñigo GabilondoBiocruces-Bizkaia Health Research Institute, Barakaldo, Spain; IKERBASQUE, The Basque Foundation for Science, Bilbao, Spain.
Sebastiano StramagliaDipartamento Interateneo di Fisica, Universita di Bari, and INFN, Sezione di Bari, Italy.
Juan Carlos Arango-LasprillaBiocruces-Bizkaia Health Research Institute, Barakaldo, Spain; IKERBASQUE, The Basque Foundation for Science, Bilbao, Spain; Department of Cell Biology and Histology, University of the Basque Country (UPV/EHU), Leioa, Spain.
Jesus M CortesBiocruces-Bizkaia Health Research Institute, Barakaldo, Spain; IKERBASQUE, The Basque Foundation for Science, Bilbao, Spain; Department of Cell Biology and Histology, University of the Basque Country (UPV/EHU), Leioa, Spain. Electronic address: jesus.cortesdiaz@osakidetza.eus.
BioCruces Health research Institute · ESHospital de Cruces · ESIkerbasque · ESUniversity of the Basque Country · ESGordon Center for Medical Imaging · USIstituto Nazionale di Fisica Nucleare, Sezione di Bari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiorgan failure (MOF) is a life-threating condition that affects two or more systems of organs not involved in the disorder that motivates admission to an Intensive Care Unit (ICU). Patients who survive MOF frequently present long-term functional, neurological, cognitive, and psychiatric sequelae. However, the changes to the brain that explain such symptoms remain unclear.

objectiveTo determine brain connectivity and cognitive functioning differences between a group of MOF patients six months after ICU discharge and healthy controls (HC).

methods22 MOF patients and 22 HC matched by age, sex, and years of education were recruited. Both groups were administered a 3T magnetic resonance imaging (MRI), including structural T1 and functional BOLD, as well as a comprehensive neuropsychological evaluation that included tests of learning and memory, speed of information processing and attention, executive function, visual constructional abilities, and language. Voxel-based morphometry was used to analyses T1 images. For the functional data at rest, functional connectivity (FC) analyses were performed.

resultsThere were no significant differences in structural imaging and neuropsychological performance between groups, even though patients with MOF performed worse in all the cognitive tests. Functional neuroimaging in the default mode network (DMN) showed hyper-connectivity towards sensory-motor, cerebellum, and visual networks. DMN connectivity had a significant association with the severity of MOF during ICU stay and with the neuropsychological scores in tests of attention and visual constructional abilities.

conclusionsIn MOF patients without structural brain injury, DMN connectivity six months after ICU discharge is associated with MOF severity and neuropsychological impairment, which supports the use of resting-state functional MRI as a potential tool to predict the onset of long-term cognitive deficits in these patients. Similar to what occurs at the onset of other pathologies, the observed hyper-connectivity might suggest network re-adaptation following MOF.

Indexed as

AdultBrainCognitive DysfunctionCross-Sectional StudiesDefault Mode NetworkFemaleHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedMultiple Organ FailureDefault Mode NetworkFunctional connectivityHyper-connectivityMultiorgan failureMultiple organ dysfunction syndromeNeuropsychological EvaluationResting state

Identifiers

PMID31931402
PMCPMC6957787
OpenAlexW2998286687

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.