Evidence map›Paper›PMID 31931008›Full record

ArticleJournal of molecular biology2020

Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site.

Michael J Rudolph, Timothy F Czajka, Simon A Davis, Chi My Thi Nguyen, Xiao-Ping Li, Nilgun E Tumer, David J Vance, Nicholas J Mantis

Open access · greenAbstract read
In one paragraph

Article in Journal of molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. AVIDbase: A biologically accurate structural dataset of nanobody-antigen complexes.Protein science : a publication of the Protein Society · 2026
    Article
  2. Article
  3. Article
  4. A Rapid and Modular Nanobody Assay for Plug-and-Play Antigen Detection.bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. An intracellular nanobody targeting T4SS effector inhibitsProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Michael J RudolphNew York Structural Biology Center, New York, NY 10027, United States. Electronic address: mrudolph@nysbc.org.
Timothy F CzajkaDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY, 12208, United States; Department of Biomedical Sciences, University at Albany, Albany, NY 12201, United States.
Simon A DavisNew York Structural Biology Center, New York, NY 10027, United States.
Chi My Thi NguyenNew York Structural Biology Center, New York, NY 10027, United States.
Xiao-Ping LiDepartment of Plant Biology, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, United States.
Nilgun E TumerDepartment of Plant Biology, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, United States.
David J VanceDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY, 12208, United States.
Nicholas J MantisDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY, 12208, United States; Department of Biomedical Sciences, University at Albany, Albany, NY 12201, United States. Electronic address: nicholas.mantis@health.ny.gov.
New York Structural Biology Center · USRutgers, The State University of New Jersey · USNew York State Department of Health · USWadsworth Center · US

Funding

NIAID NIH HHS HHSN272201400021C
6 · The paper itself

Abstract

The extreme potency of the plant toxin, ricin, is due to its enzymatic subunit, RTA, which inactivates mammalian ribosomes with near-perfect efficiency. Here we characterized, at the functional and structural levels, seven alpaca single-domain antibodies (V

Indexed as

AnimalsAntibodies, NeutralizingBinding Sites, AntibodyCatalytic DomainChlorocebus aethiopsEnzyme-Linked Immunosorbent AssayPolymerase Chain ReactionRicinSingle-Domain AntibodiesSurface Plasmon ResonanceVero CellsAntibodies, NeutralizingRicinSingle-Domain AntibodiesAntibodyIntracellularStructureToxin

Identifiers

PMID31931008
PMCPMC7066583
OpenAlexW3000280028

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.