ArticlePlant biotechnology journal2020
Metabolite-based genome-wide association study enables dissection of the flavonoid decoration pathway of wheat kernels.
Article in Plant biotechnology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 2 of them syntheses that pooled it.
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Who cites it
87 citing papers in PubMed, 2 syntheses or guidelines pooled it, 170 citations in OpenAlex.
- Exploring and exploiting genetics and genomics for sweetpotato improvement: Status and perspectives.Plant communications · 2022Pooled it
- Multi-omics revolution to promote plant breeding efficiency.Frontiers in plant science · 2022Pooled it
- Low temperature modulates spike development and yieldaBIOTECH · 2026Article
- Plasticity of metabolism in plants.The Plant journal : for cell and molecular biology · 2026Review
- Comparative Genome-Wide Association Studies of Metabolites and Grain-Related Traits in Common Wheat.Plant biotechnology journal · 2026Article
- Functional divergence of BnaWRKY7 homologs drives phytosterol variations in polyploid Brassica napus.Journal of advanced research · 2026Article
- Evolutionary origin of neohesperidoside, a bitter metabolite, and its potential role in biotic defense and citrus dissemination.Plant communications · 2026Article
- Unveiling Plant Metabolic Diversity: Integrating Metabolomics with Multi-Omics Approaches for Crop Improvement.Plants (Basel, Switzerland) · 2026Review
- Joint analysis of GWAS and TILLING reveals the negative role of GLABRA2 in controlling seed oil content in Brassica napus.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- A 6-bp deletion in the R2R3-MYB domain of the SmFAP1 gene disrupts DNA-binding capacity and leads to anthocyanin deficiency in eggplant peels.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Omics Sciences: Driving the Conservation and Characterization of Plant Genetic Resources.Methods in molecular biology (Clifton, N.J.) · 2026Review
- Integrating predictive models and GWAS to identify candidate loci and genes for agronomic traits in rice.Frontiers in plant science · 2026Article
- Learning from nature: phytochemical strategies to protect against UV-B damage.Nature communications · 2025Review
- Adjustments of plant primary metabolism in the face of climate change.Journal of experimental botany · 2025Review
- Marker Metabolite-Based Multi-Omics Analysis Identifies New Loci Controlling Thousand Seed Weight in Brassica Napus.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Genome-wide dissection of lesion mimic mutations in wheat: identification and functional characterization of candidate genes.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Differential Metabolic Analysis of Rhizomes in Shancigu Based on Widely Targeted Metabolomics.Metabolites · 2025Article
- Smarter stomata: emergent technologies unlocking yield potential in a changing climate.AoB PLANTS · 2025Review
- Transcriptome-wide identification and systematic analysis of the Retrotransposon genes and their roles in ginsenoside biosynthesis in Panax ginseng.BMC plant biology · 2025Article
- Unraveling the regulatory network of barley grain metabolism through the integrative analysis of multiomics and mQTL.Nature communications · 2025Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The marriage of metabolomic approaches with genetic design has proven a powerful tool in dissecting diversity in the metabolome and has additionally enhanced our understanding of complex traits. That said, such studies have rarely been carried out in wheat. In this study, we detected 805 metabolites from wheat kernels and profiled their relative contents among 182 wheat accessions, conducting a metabolite-based genome-wide association study (mGWAS) utilizing 14 646 previously described polymorphic SNP markers. A total of 1098 mGWAS associations were detected with large effects, within which 26 candidate genes were tentatively designated for 42 loci. Enzymatic assay of two candidates indicated they could catalyse glucosylation and subsequent malonylation of various flavonoids and thereby the major flavonoid decoration pathway of wheat kernel was dissected. Moreover, numerous high-confidence genes associated with metabolite contents have been provided, as well as more subdivided metabolite networks which are yet to be explored within our data. These combined efforts presented the first step towards realizing metabolomics-associated breeding of wheat.
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