ArticleMovement disorders : official journal of the Movement Disorder Society2020
Normal Temporal Discrimination in Musician's Dystonia Is Linked to Aberrant Sensorimotor Processing.
Article in Movement disorders : official journal of the Movement Disorder Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03042962 (Brain Networks in Dystonia), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Brain Networks in Dystonia
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Structural and functional brain alterations in laryngeal dystonia: A coordinate-based activation likelihood estimation meta-analysis.Human brain mapping · 2024Pooled it
- Brain-Computer Interface Improves Symptoms of Isolated Focal Laryngeal Dystonia: A Single-Blind Study.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Brain network pathophysiology in dystonia.Dystonia (Lausanne, Switzerland) · 2025Article
- Temporal Signature of Task-Specificity in Isolated Focal Laryngeal Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- Sensory processing in the auditory and olfactory domains is normal in laryngeal dystonia.Journal of neurology · 2023Article
- DystoniaBoTXNet: Novel Neural Network Biomarker of Botulinum Toxin Efficacy in Isolated Dystonia.Annals of neurology · 2023Article
- Sensorimotor Incoordination in Musicians' Dystonia.Advances in neurobiology · 2023Article
- Neuromodulation in Dystonia - Harnessing the Network.Advances in neurobiology · 2023Article
- Short- and Long-term Central Action of Botulinum Neurotoxin Treatment in Laryngeal Dystonia.Neurology · 2022Article
- Characterizing the temporal discrimination threshold in musician's dystonia.Scientific reports · 2022Article
- Functional MRI connectivity of the primary motor cortex in functional dystonia patients.Journal of neurology · 2022Article
- Impaired feedforward control of movements in pianists with focal dystonia.Frontiers in neurology · 2022Article
- Laryngeal Dystonia: Multidisciplinary Update on Terminology, Pathophysiology, and Research Priorities.Neurology · 2021Review
- Neural endophenotypes and predictors of laryngeal dystonia penetrance and manifestation.Neurobiology of disease · 2021Article
- The large-scale structural connectome of task-specific focal dystonia.Human brain mapping · 2020Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesAlterations in sensory discrimination are a prominent nonmotor feature of dystonia. Abnormal temporal discrimination in focal dystonia is considered to represent its mediational endophenotype, albeit unclear pathophysiological correlates. We examined the associations between the visual temporal discrimination threshold (TDT) and brain activity in patients with musician's dystonia, nonmusician's dystonia, and healthy controls.
methodsA total of 42 patients and 41 healthy controls participated in the study. Between-group differences in TDT z scores were computed using inferential statistics. Statistical associations of TDT z scores with clinical characteristics of dystonia and resting-state functional brain activity were examined using nonparametric rank correlations.
resultsThe TDT z scores of healthy controls were significantly different from those of patients with nonmusician's dystonia, but not of patients with musician's dystonia. Healthy controls showed a significant relationship between normal TDT levels and activity in the inferior parietal cortex. This relationship was lost in all patients. Instead, TDT z scores in musician's dystonia established additional correlations with activity in premotor, primary somatosensory, ventral extrastriate cortices, inferior occipital gyrus, precuneus, and cerebellum, whereas nonmusician's dystonia showed a trending correlation in the lingual gyrus extending to the cerebellar vermis. There were no significant relationships between TDT z scores and dystonia onset, duration, or severity.
conclusionsTDT assessment as an endophenotypic marker may only be relevant to nonmusician forms of dystonia because of the lack of apparent alterations in musician's dystonia. Compensatory adaptation of neural circuitry responsible for TDT processing likely adjusted the TDT performance to the behaviorally normal levels in patients with musician's dystonia, but not nonmusician's dystonia. © 2020 International Parkinson and Movement Disorder Society.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.