Evidence map›Paper›PMID 31930524›Full record

ReviewImmunological reviews2020

Immune checkpoint inhibitor-induced inflammatory arthritis as a model of autoimmune arthritis.

Laura C Cappelli, Mekha A Thomas, Clifton O Bingham, Ami A Shah, Erika Darrah

Abstract readReview
In one paragraph

Review in Immunological reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Immune Checkpoint Inhibitor-Associated Inflammatory Arthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Genes · 2024
    Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Clonally expanded CD38Science immunology · 2023
    Article
  15. Article
  16. Review
  17. Article
  18. Observational
  19. Article
  20. A20: a master regulator of arthritis.Arthritis research & therapy · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Laura C CappelliDivision of Rheumatology, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-2795-7059
Mekha A ThomasDivision of Rheumatology, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-5169-6568
Clifton O BinghamDivision of Rheumatology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Ami A ShahDivision of Rheumatology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Erika DarrahDivision of Rheumatology, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-1119-0279

Funding

Sample Processing and Immunoassay Research CoreP30AR070254 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI Antony Rosen · 2016 to 2026
$8.9M
Autoantibodies Define Scleroderma Subgroups with Distinct Relationships to CancerR01AR073208 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI LIVIA A CASCIOLA-ROSEN, Ami Aalok Shah · 2018 to 2026
$5.2M
Understanding Inflammatory Arthritis due to Immune Checkpoint InhibitorsK23AR075872 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI CAPPELLI, LAURA CHRISTINE · 2019 to 2023
$779k
NIAMS NIH HHS K23 AR075872NIAMS NIH HHS P30 AR070254NIAMS NIH HHS R01 AR073208NIAMS NIH HHS R01-AR073208
6 · The paper itself

Abstract

The development of inflammatory arthritis in patients receiving immune checkpoint inhibitor therapy is increasingly recognized due to the growing use of these drugs for the treatment of cancer. This represents an important opportunity not only to define the mechanisms responsible for the development of this immune-related adverse event and to ultimately predict or prevent its development, but also to provide a unique window into early events in the development of inflammatory arthritis. Knowledge gained through the study of this patient population, for which the inciting event is known, could shed light into the pathogenesis of autoimmune arthritis. This review will highlight the clinical and immunologic features of these entities to define common elements for future study.

Indexed as

AnimalsArthritisArthritis, RheumatoidAutoimmune DiseasesDrug-Related Side Effects and Adverse ReactionsHumansImmune Checkpoint InhibitorsImmune Checkpoint ProteinsNeoplasmsImmune Checkpoint InhibitorsImmune Checkpoint Proteinsautoimmunitycancerimmune checkpoint inhibitorimmune-related adverse eventrheumatoid arthritisspondyloarthropathy

Identifiers

PMID31930524
PMCPMC7047521

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.