Evidence map›Paper›PMID 31930458›Full record

ArticleCell and tissue research2020

Vitamin D strengthens the bladder epithelial barrier by inducing tight junction proteins during E. coli urinary tract infection.

Soumitra Mohanty, Witchuda Kamolvit, Olof Hertting, Annelie Brauner

Open access · hybridAbstract read
In one paragraph

Article in Cell and tissue research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Association between vitamin D levels and urinary tract infections.Caspian journal of internal medicine · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Cholecalciferol Exhibits no Antibacterial Effect onRecent advances in anti-infective drug discovery · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Soumitra MohantyDepartment of Microbiology, Tumor and Cell Biology, Division of Clinical Microbiology, Karolinska Institutet and Karolinska University Hospital, SE-17176, Stockholm, Sweden.
Witchuda KamolvitDepartment of Microbiology, Tumor and Cell Biology, Division of Clinical Microbiology, Karolinska Institutet and Karolinska University Hospital, SE-17176, Stockholm, Sweden.
Olof HerttingDepartment of Microbiology, Tumor and Cell Biology, Division of Clinical Microbiology, Karolinska Institutet and Karolinska University Hospital, SE-17176, Stockholm, Sweden.
Annelie BraunerDepartment of Microbiology, Tumor and Cell Biology, Division of Clinical Microbiology, Karolinska Institutet and Karolinska University Hospital, SE-17176, Stockholm, Sweden. Annelie.Brauner@ki.se.ORCID http://orcid.org/0000-0001-5533-6837
Karolinska University Hospital · SE

Funding

Karolinska Institutet NASiriraj Hospital Mahidol University NAStiftelsen Olle Engkvist Byggmästare NAStockholm County Council (ALF project) NASwedish Neurological Association NA
6 · The paper itself

Abstract

Tight junction proteins are pivotal to prevent bacterial invasion of the epithelial barrier. We here report that supplementation with vitamin D can strengthen the urinary bladder lining. Vitamin D deficient and sufficient mice were infected with Escherichia coli (E. coli) transurethrally to cause urinary tract infection. In addition, bladder biopsies were obtained from postmenopausal women before and after a 3-month period of supplementation with 25-hydroxyvitamin D

Indexed as

AnimalsClaudinsEpithelial CellsEpitheliumEscherichia coliEscherichia coli InfectionsFemaleHumansMiceMice, Inbred C57BLOccludinPostmenopauseUrinary BladderUrinary Tract InfectionsVitamin Dclaudin 14ClaudinsOccludinOCLN protein, humanVitamin DClaudin-14Escherichia coliOccludinUrinary bladderVitamin D

Identifiers

PMID31930458
PMCPMC7242269
OpenAlexW2999358931

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.