ArticleInternational journal of colorectal disease2020
Use of intravenous iron therapy in colorectal cancer patient with iron deficiency anemia: a propensity-score matched study.
Article in International journal of colorectal disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Intravenous iron and iron deficiency anemia in patients with gastrointestinal cancer: A systematic review.PloS one · 2024Pooled it
- Adverse events of iron and/or erythropoiesis-stimulating agent therapy in preoperatively anemic elective surgery patients: a systematic review.Systematic reviews · 2022Pooled it
- Review
- Article
- Preoperative Anemia and Iron Deficiency in Elective Gastrointestinal Cancer Surgery Patients.Journal of surgical oncology · 2025Article
- An overview of the current evidences on the role of iron in colorectal cancer: a review.Frontiers in oncology · 2025Review
- Efficacy and safety of preoperative intravenous iron versus standard care in colorectal cancer patients with iron deficiency anemia: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2024Article
- Streamlined Preoperative Iron Deficiency Screening and IV Treatment for Colorectal Cancer Patients beyond Clinical Trials.Journal of clinical medicine · 2024Article
- Iron Surveillance and Management in Gastro-Intestinal Oncology Patients: A National Physician Survey.Current oncology (Toronto, Ont.) · 2023Article
- Article
- Review
- Preoperative intravenous iron treatment reduces postoperative complications and postoperative anemia in preoperatively anemic patients with colon carcinoma.International journal of colorectal disease · 2022Article
- Preoperative iron status is a prognosis factor for stage II and III colorectal cancer.International journal of clinical oncology · 2021Article
- Need for preoperative anemia management clinics in Japan: initiatives at a university hospital in the USA.Journal of anesthesia · 2021Article
- Oral iron supplementation after antibiotic exposure induces a deleterious recovery of the gut microbiota.BMC microbiology · 2021Article
- The Ideal Time for Iron Administration in Anemia Secondary to Blood Loss-An Experimental Animal Model.Life (Basel, Switzerland) · 2021Article
- Anaesthesia as an influence in tumour progression.Langenbeck's archives of surgery · 2021Review
- Flipside of the Coin: Iron Deficiency and Colorectal Cancer.Frontiers in immunology · 2021Review
- Iron Deficiency Anemia in Colorectal Cancer Patients: Is Preoperative Intravenous Iron Infusion Indicated? A Narrative Review of the Literature.Cancer diagnosis & prognosisReview
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIron deficiency anemia is common in colorectal cancer patients and is related to poor surgical outcome. Increasing evidence supports preoperative use of intravenous iron (IVI) to correct anemia. Our study investigates effect of preoperative IVI on hemoglobin level.
methodsFrom August 2017 to March 2019, colorectal cancer patients with iron deficiency anemia received intravenous iron at least 2 weeks before their scheduled operations (IVI group). These patients' prospectively collected data were compared to a historic cohort of anemic patients who received elective colorectal surgery within 3 years before the study period (non-IVI).
resultsForty-six patients were included after receiving intravenous iron. After propensity score matching on 1:2 ratio, 38 patients in IVI group were matched with 62 patients from non-IVI group. There was no statistical difference for preoperative mean hemoglobin level between the two groups (8.43 g/dL in IVI, 8.79 g/dL in non-IVI, p = 0.117), but IVI group has significantly higher mean hemoglobin level on admission (10.63 g/dL in IVI, 9.46 g/dL in non-IVI, p = < 0.001). IVI group had higher median hemoglobin rise (1.9 in IVI, 0.6 in non-IVI, p = <0.001) and significantly less red cell transfusion (8 patients in IVI, 30 in non-IVI, p = 0.006). Subgroup analysis showed that less patients in IVI group required transfusions in preoperative period (1 in IVI group, 20 in non-IVI, p < 0.001).
conclusionOur data suggested that IVI can significantly increase hemoglobin level in iron deficiency anemic patients before colorectal surgery, with reduction in red cell transfusions.
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