Evidence map›Paper›PMID 31930318›Full record

ArticleSleep2020

Associations between migraine attacks and nightly sleep characteristics among adults with episodic migraine: a prospective cohort study.

Angeliki Vgontzas, Wenyuan Li, Elizabeth Mostofsky, Michael Rueschman, Murray A Mittleman, Suzanne M Bertisch

Open access · bronzeAbstract read
In one paragraph

Article in Sleep, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. The chronobiology of migraine: a systematic review.The journal of headache and pain · 2021
    Pooled it
  4. Article
  5. Sleep and Headache Disorders: What a Clinician Needs to Know.Current neurology and neuroscience reports · 2026
    Review
  6. The effect of standard time to daylight-saving clock transition on sleep and migraine headaches.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
    Observational
  7. Article
  8. Article
  9. Review
  10. Review
  11. The association between multidimensional sleep health and migraine burden among patients with episodic migraine.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023
    Article
  12. Changes in the rest-activity rhythm in migraine patients are associated with anxiety symptoms.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2022
    Article
  13. Article
  14. Article
  15. Habitual sleep disturbances and migraine: a Mendelian randomization study.Annals of clinical and translational neurology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Angeliki VgontzasDepartment of Neurology, Brigham and Women's Hospital, Boston, MA.
Wenyuan LiDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA.
Elizabeth MostofskyDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA.
Michael RueschmanProgram in Sleep Medicine Epidemiology, Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Murray A MittlemanHarvard Medical School, Boston, MA.
Suzanne M BertischHarvard Medical School, Boston, MA.
Beth Israel Deaconess Medical Center · USHarvard University · USBrigham and Women's Hospital · USCanadian Sleep & Circadian Network · CA

Funding

Alcohol and Breast Cancer: Genetic Interactions and Effects on Aromatase Inhibitor TherapyK01AA027831 · NIAAA · HARVARD SCHOOL OF PUBLIC HEALTH · PI MOSTOFSKY, ELIZABETH · 2019 to 2023
$820k
NIAAA NIH HHS K01 AA027831
6 · The paper itself

Abstract

STUDY

objectivesGiven the unknown immediate impact of migraine on nighttime sleep, we prospectively examined whether migraine headaches were associated with subsequent shorter sleep duration, higher fragmentation, and poorer quality in a cohort of 98 adults with episodic migraine.

methodsParticipants completed twice-daily electronic diaries and wore actigraphs continuously for 6 weeks. We examined whether days with headaches were associated with changes in that night's sleep characteristics compared with headache-free days, using adjusted multivariable linear mixed models with subject-specific intercepts.

resultsParticipants were 35 ± 12 years old, 88% women, with an average of five migraine headaches per month. Over 4,406 days, we observed 1,077 headache days, representing 823 discrete headaches. Average nightly objective sleep duration was 7.3 ± 1.2 hr, efficiency 89.5 ± 3.3%, and wake after sleep onset (WASO) 44.8 ± 17.0 min. Objective sleep duration was 7.3 min (95% CI: 1.5, 13.0) longer on nights following a headache day compared with nights on a headache-free day. Objective sleep efficiency, WASO, and reported sleep quality were not significantly different on headache days compared with headache-free days (sleep efficiency: -0.06 min, 95% CI: -0.3, 0.2; WASO 1.5 min, 95% CI: 0.0, 3.0; sleep quality: 1.0, 95% CI: 0.8, 1.3).

conclusionsSleep periods immediately following migraine headaches are not associated with shorter duration, higher disruption, or poorer sleep quality in patients with episodic migraine. These results suggest that clinical evaluation of sleep disturbance in patients with episodic migraine should be approached independently of their migraine status.

Indexed as

Migraine DisordersSleep Wake DisordersAdultCohort StudiesFemaleHumansMaleMiddle AgedProspective StudiesSleepYoung Adultactigraphyepidemiologymigrainepain

Identifiers

PMID31930318
PMCPMC7355393
OpenAlexW3000058396

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.